Component

Parabacteroides goldsteinii

Parabacteroides goldsteinii

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.

    Parabacteroides goldsteinii → Apigenin Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    experimental_model
    Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.
    primary_references
    Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008
    source_locator
    Reviewed reference api-bacterial-production; Human abundance/metabolite associations are observational. The plant-like biosynthetic pathway was not completely reconstituted.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 472–478

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements. · Recorded from source · Recorded from source

    ### api-bacterial-production The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements. Human abundance/metabolite associations are observational. The plant-like biosynthetic pathway was not completely reconstituted. Model and exposure: Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.

    Parabacteroides goldsteinii AmpB candidate biosynthetic protein → Apigenin Recorded from sourceungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    experimental_contrast
    {"intervention": "ampB knockout", "comparator": "Wild-type bacterium", "endpoint": "Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Bacterial knockout and mouse colonization experiments.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.
    primary_references
    Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008
    source_locator
    Reviewed reference api-ampb-loss; Supports a genetic requirement in this model; docking and structural similarity do not by themselves prove AmpB is a purified chalcone synthase.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 480–486

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Bacterial knockout and mouse colonization experiments. · Recorded from source · Recorded from source

    ### api-ampb-loss Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model. Supports a genetic requirement in this model; docking and structural similarity do not by themselves prove AmpB is a purified chalcone synthase. Model and exposure: Bacterial knockout and mouse colonization experiments. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.