Component
Parabacteroides goldsteinii AmpB candidate biosynthetic protein
Parabacteroides goldsteinii AmpB candidate biosynthetic protein
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
- experimental_contrast
- {"intervention": "ampB knockout", "comparator": "Wild-type bacterium", "endpoint": "Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
- experimental_model
- Bacterial knockout and mouse colonization experiments.
- interpretation_status
- Recorded from source with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
- plain_language
- Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model.
- primary_references
- Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008
- source_locator
- Reviewed reference api-ampb-loss; Supports a genetic requirement in this model; docking and structural similarity do not by themselves prove AmpB is a purified chalcone synthase.
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 480–486
AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Bacterial knockout and mouse colonization experiments. · Recorded from source · Recorded from source
### api-ampb-loss Deleting bacterial ampB eliminated the reported apigenin signal without the same loss of growth or colonization in the tested P. goldsteinii model. Supports a genetic requirement in this model; docking and structural similarity do not by themselves prove AmpB is a purified chalcone synthase. Model and exposure: Bacterial knockout and mouse colonization experiments. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.