{"id":"ec71667a-3a90-5b57-854a-d89fb3951d8d","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-bacterial-production","predicate":"reported_relationship","statement":"The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.","claim_class":"mechanistic","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"022900ce-6529-5ac0-b4b1-a7295cb3a185","mechanism_event_label":"The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.","subject":{"id":"528bf013-ff85-5bdb-8551-5b83d990c741","slug":"pgoldsteinii","display_name":"Parabacteroides goldsteinii","entity_type_key":"organism"},"object":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"022900ce-6529-5ac0-b4b1-a7295cb3a185","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-bacterial-production-event","event_type":"biochemical_relationship","label":"The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.","description":"### api-bacterial-production\n\nThe investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.\nHuman abundance/metabolite associations are observational. The plant-like biosynthetic pathway was not completely reconstituted.\nModel and exposure: Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"528bf013-ff85-5bdb-8551-5b83d990c741","slug":"pgoldsteinii","display_name":"Parabacteroides goldsteinii","entity_type_key":"organism"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-bacterial-production; Human abundance/metabolite associations are observational. The plant-like biosynthetic pathway was not completely reconstituted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"890735ce-bed5-5ee2-8df8-a82414357fc6","evidence_kind":"source_excerpt","locator":"Lines 472-478","start_line":472,"end_line":478,"excerpt":"### api-bacterial-production\n\nThe investigators detected apigenin in P. goldsteinii culture preparations by LC-MS and linked bacterial administration to host apigenin measurements.\nHuman abundance/metabolite associations are observational. The plant-like biosynthetic pathway was not completely reconstituted.\nModel and exposure: Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"Cultured bacterium, germ-free/aged mouse experiments and metabolite measurements.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. 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