Component
Overt biochemical thyrotoxicosis incidence
Overt biochemical thyrotoxicosis incidence. Study-specific scope and measurement methods are recorded with each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After iodization, standardized thyrotoxicosis incidence initially rose 39% in the previously moderately deficient cohort and 52% in the mildly deficient cohort, peaking in 2000–2001 and 2004–2005 respectively.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary indexed abstract.
- experimental_model
- Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents
- exposure
- Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.
- limitations
- Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- Thyrotoxicosis increased during the early years after iodine supply changed.
- primary_references
- [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751
- tissue_or_cell_type
- Incident overt biochemical thyrotoxicosis identified from thyroid tests
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1510–1522
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents · source_derived_draft · unverified_draft
### iod-clin-danish-early-rise After iodization, standardized thyrotoxicosis incidence initially rose 39% in the previously moderately deficient cohort and 52% in the mildly deficient cohort, peaking in 2000–2001 and 2004–2005 respectively. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Thyrotoxicosis increased during the early years after iodine supply changed. organism: Homo sapiens tissue_or_cell_type: Incident overt biochemical thyrotoxicosis identified from thyroid tests experimental_model: Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents limitations: Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims. exposure: Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017. cross_nutrient: false evidence_location: Primary indexed abstract. [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751
Complete structured claim and evidenceIncidence returned to baseline or below by 2008; in the western, previously moderately deficient cohort it was 33% below baseline in 2016–2017.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary indexed abstract.
- experimental_model
- Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents
- exposure
- Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.
- limitations
- Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims. Only the western cohort continued to 2017. The decline was strongest among older people; this is not a claim that every thyroid outcome improved.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- The later population pattern differed from the early rise.
- primary_references
- [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751
- tissue_or_cell_type
- Incident overt biochemical thyrotoxicosis identified from thyroid tests
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1524–1536
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents · source_derived_draft · unverified_draft
### iod-clin-danish-late-decline Incidence returned to baseline or below by 2008; in the western, previously moderately deficient cohort it was 33% below baseline in 2016–2017. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The later population pattern differed from the early rise. organism: Homo sapiens tissue_or_cell_type: Incident overt biochemical thyrotoxicosis identified from thyroid tests experimental_model: Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents limitations: Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims. Only the western cohort continued to 2017. The decline was strongest among older people; this is not a claim that every thyroid outcome improved. exposure: Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017. cross_nutrient: false evidence_location: Primary indexed abstract. [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.