{"id":"3ea275f1-22fc-559b-a5a3-890d30404520","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-danish-late-decline","predicate":"longer-follow-up-associated-with-decline-in","statement":"Incidence returned to baseline or below by 2008; in the western, previously moderately deficient cohort it was 33% below baseline in 2016–2017.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6f447268-51e7-5202-95df-2b17dbfa4c3e","mechanism_event_label":"The later population pattern differed from the early rise.","subject":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"object":{"id":"76965bf6-33d6-5600-80d8-b7a5e1af7439","slug":"overt-thyrotoxicosis-incidence","display_name":"Overt biochemical thyrotoxicosis incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f447268-51e7-5202-95df-2b17dbfa4c3e","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-danish-late-decline-event","event_type":"observed_intervention","label":"The later population pattern differed from the early rise.","description":"Incidence returned to baseline or below by 2008; in the western, previously moderately deficient cohort it was 33% below baseline in 2016–2017.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"fortified nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"76965bf6-33d6-5600-80d8-b7a5e1af7439","slug":"overt-thyrotoxicosis-incidence","display_name":"Overt biochemical thyrotoxicosis incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims. Only the western cohort continued to 2017. The decline was strongest among older people; this is not a claim that every thyroid outcome improved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The later population pattern differed from the early rise.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Incident overt biochemical thyrotoxicosis identified from thyroid tests","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eecd6f1a-6c3c-5577-99c5-a0809187f968","evidence_kind":"source_excerpt","locator":"Lines 1524-1536","start_line":1524,"end_line":1536,"excerpt":"### iod-clin-danish-late-decline\nIncidence returned to baseline or below by 2008; in the western, previously moderately deficient cohort it was 33% below baseline in 2016–2017.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The later population pattern differed from the early rise.\norganism: Homo sapiens\ntissue_or_cell_type: Incident overt biochemical thyrotoxicosis identified from thyroid tests\nexperimental_model: Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents\nlimitations: Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims. Only the western cohort continued to 2017. The decline was strongest among older people; this is not a claim that every thyroid outcome improved.\nexposure: Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751","model_system":"Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}