{"id":"ca9075db-01c4-5b29-88c2-0dcc6184e890","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-danish-early-rise","predicate":"early-fortification-associated-with-rise-in","statement":"After iodization, standardized thyrotoxicosis incidence initially rose 39% in the previously moderately deficient cohort and 52% in the mildly deficient cohort, peaking in 2000–2001 and 2004–2005 respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e2302e19-9881-5647-b668-86b21599b887","mechanism_event_label":"Thyrotoxicosis increased during the early years after iodine supply changed.","subject":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"object":{"id":"76965bf6-33d6-5600-80d8-b7a5e1af7439","slug":"overt-thyrotoxicosis-incidence","display_name":"Overt biochemical thyrotoxicosis incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2302e19-9881-5647-b668-86b21599b887","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-danish-early-rise-event","event_type":"observed_intervention","label":"Thyrotoxicosis increased during the early years after iodine supply changed.","description":"After iodization, standardized thyrotoxicosis incidence initially rose 39% in the previously moderately deficient cohort and 52% in the mildly deficient cohort, peaking in 2000–2001 and 2004–2005 respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"fortified nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"76965bf6-33d6-5600-80d8-b7a5e1af7439","slug":"overt-thyrotoxicosis-incidence","display_name":"Overt biochemical thyrotoxicosis incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Thyrotoxicosis increased during the early years after iodine supply changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Incident overt biochemical thyrotoxicosis identified from thyroid tests","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b489ddc8-5621-5b1a-9fdf-5b4daf6c3d6f","evidence_kind":"source_excerpt","locator":"Lines 1510-1522","start_line":1510,"end_line":1522,"excerpt":"### iod-clin-danish-early-rise\nAfter iodization, standardized thyrotoxicosis incidence initially rose 39% in the previously moderately deficient cohort and 52% in the mildly deficient cohort, peaking in 2000–2001 and 2004–2005 respectively.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Thyrotoxicosis increased during the early years after iodine supply changed.\norganism: Homo sapiens\ntissue_or_cell_type: Incident overt biochemical thyrotoxicosis identified from thyroid tests\nexperimental_model: Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents\nlimitations: Population trend rather than randomized individual causation; age composition, diagnostic testing and prior thyroid autonomy can influence rates. Early rise and later fall are successive phases, not competing claims.\nexposure: Mandatory salt iodization at 13 ppm from mid 2000; western cohort previously moderately deficient and eastern mildly deficient; eastern follow-up only through 2008, western through 2017.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. (2018). https://pubmed.ncbi.nlm.nih.gov/29851122/ DOI: 10.1111/cen.13751","model_system":"Twenty-one-year prospective population-register study in two open Danish cohorts, initially 533969 residents","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-denmark2018] Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. 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