Component
Circulating NT-proBNP
Circulating NT-proBNP. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 16-week NT-proBNP, NYHA-class and six-minute-walk endpoints did not significantly change between trial groups.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"}
- experimental_model
- Q-SYMBIO randomized double-blind multicenter trial
- exposure
- 100 mg CoQ10 three times daily added to standard therapy
- limitations
- One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- 420 patients with moderate-to-severe chronic heart failure
- plain_language
- The early markers did not mirror the later event finding.
- primary_references
- [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
- tissue_or_cell_type
- Short-term function and two-year clinical events
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1113–1124
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Q-SYMBIO randomized double-blind multicenter trial · source_derived_draft · unverified_draft
### coq10-heart-failure-short The 16-week NT-proBNP, NYHA-class and six-minute-walk endpoints did not significantly change between trial groups. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The early markers did not mirror the later event finding. organism: 420 patients with moderate-to-severe chronic heart failure tissue_or_cell_type: Short-term function and two-year clinical events experimental_model: Q-SYMBIO randomized double-blind multicenter trial limitations: One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment. exposure: 100 mg CoQ10 three times daily added to standard therapy evidence_span: {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"} [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
Complete structured claim and evidenceMean NT-proBNP at 48 months was 214 ng/L in the combined-treatment group versus 302 ng/L with placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/22626835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587", "start_char": 0, "end_char": 1797, "text_sha256": "68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587"}
- experimental_model
- Randomized double-blind combined-supplement trial
- exposure
- Selenium plus CoQ10 versus placebo; 5.2-year follow-up
- limitations
- Combined intervention without selenium-only and CoQ-only arms; no independent CoQ effect or statistical nutrient synergy can be identified.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- 443 Swedish adults aged 70-88
- plain_language
- A heart-stress marker also differed; this was the same trial, not an independent replication.
- primary_references
- [coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. (2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156
- tissue_or_cell_type
- Cardiovascular mortality and cardiac measurements
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1139–1150
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind combined-supplement trial · source_derived_draft · unverified_draft
### coq10-selenium-combination-marker Mean NT-proBNP at 48 months was 214 ng/L in the combined-treatment group versus 302 ng/L with placebo. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A heart-stress marker also differed; this was the same trial, not an independent replication. organism: 443 Swedish adults aged 70-88 tissue_or_cell_type: Cardiovascular mortality and cardiac measurements experimental_model: Randomized double-blind combined-supplement trial limitations: Combined intervention without selenium-only and CoQ-only arms; no independent CoQ effect or statistical nutrient synergy can be identified. exposure: Selenium plus CoQ10 versus placebo; 5.2-year follow-up evidence_span: {"source_cache": "artifacts/coq10-research/22626835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587", "start_char": 0, "end_char": 1797, "text_sha256": "68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587"} [coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. (2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.