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(2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cardiovascular mortality and cardiac measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2e8885c8-a330-563d-956e-8a0a53fbca09","evidence_kind":"source_excerpt","locator":"Lines 1139-1150","start_line":1139,"end_line":1150,"excerpt":"### coq10-selenium-combination-marker\nMean NT-proBNP at 48 months was 214 ng/L in the combined-treatment group versus 302 ng/L with placebo.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A heart-stress marker also differed; this was the same trial, not an independent replication.\norganism: 443 Swedish adults aged 70-88\ntissue_or_cell_type: Cardiovascular mortality and cardiac measurements\nexperimental_model: Randomized double-blind combined-supplement trial\nlimitations: Combined intervention without selenium-only and CoQ-only arms; no independent CoQ effect or statistical nutrient synergy can be identified.\nexposure: Selenium plus CoQ10 versus placebo; 5.2-year follow-up\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/22626835.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\", \"start_char\": 0, \"end_char\": 1797, \"text_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\"}\n[coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. (2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156","model_system":"Randomized double-blind combined-supplement trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 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