{"id":"831895ee-6f35-5733-97b5-457420e60a70","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-heart-failure-short","predicate":"did_not_significantly_change_at_16_weeks","statement":"The 16-week NT-proBNP, NYHA-class and six-minute-walk endpoints did not significantly change between trial groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"72e91022-7851-578b-9cda-edc77b23baf0","mechanism_event_label":"The early markers did not mirror the later event finding.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"2e93aa6d-4daf-5173-a4be-4611393a5db2","slug":"nt-probnp","display_name":"Circulating NT-proBNP","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"72e91022-7851-578b-9cda-edc77b23baf0","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-heart-failure-short-event","event_type":"observed_intervention","label":"The early markers did not mirror the later event finding.","description":"The 16-week NT-proBNP, NYHA-class and six-minute-walk endpoints did not significantly change between trial groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2e93aa6d-4daf-5173-a4be-4611393a5db2","slug":"nt-probnp","display_name":"Circulating NT-proBNP","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/25282031.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65\", \"start_char\": 0, \"end_char\": 2024, \"text_sha256\": \"20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Q-SYMBIO randomized double-blind multicenter trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"100 mg CoQ10 three times daily added to standard therapy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"420 patients with moderate-to-severe chronic heart failure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The early markers did not mirror the later event finding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Short-term function and two-year clinical events","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"89162597-ce30-51b6-bc14-3c240807fd19","evidence_kind":"source_excerpt","locator":"Lines 1113-1124","start_line":1113,"end_line":1124,"excerpt":"### coq10-heart-failure-short\nThe 16-week NT-proBNP, NYHA-class and six-minute-walk endpoints did not significantly change between trial groups.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The early markers did not mirror the later event finding.\norganism: 420 patients with moderate-to-severe chronic heart failure\ntissue_or_cell_type: Short-term function and two-year clinical events\nexperimental_model: Q-SYMBIO randomized double-blind multicenter trial\nlimitations: One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment.\nexposure: 100 mg CoQ10 three times daily added to standard therapy\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/25282031.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65\", \"start_char\": 0, \"end_char\": 2024, \"text_sha256\": \"20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65\"}\n[coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008","model_system":"Q-SYMBIO randomized double-blind multicenter trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}