Component
Nitro-conjugated linoleic acid / NO2-CLA family
Context-specific entity; species, compartment and exposure are stated on each claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human albumin bound NO2-CLA noncovalently and formed covalent adducts at Cys34.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Purified protein and chemical assays.
- limitations
- Distribution was a mechanistic implication, not a measured clinical outcome.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- A circulating carrier can bind the modified lipid in two ways.
- primary_references
- The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27923813/ · DOI 10.1074/jbc.M116.756288
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 350–356
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Purified protein and chemical assays. · source_derived_draft · unverified_draft
## cla-albumin A circulating carrier can bind the modified lipid in two ways. Human albumin bound NO2-CLA noncovalently and formed covalent adducts at Cys34. Model: Purified protein and chemical assays. Limitations: Distribution was a mechanistic implication, not a measured clinical outcome. Evidence access: Primary abstract The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27923813/ · DOI 10.1074/jbc.M116.756288
Complete structured claim and evidenceNO2-CLA reacted reversibly with glutathione and other low-molecular-weight thiols through electrophilic beta and delta carbons.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Biochemical kinetic and mass-spectrometric studies.
- limitations
- Adduct formation is not proof of systemic glutathione depletion.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Glutathione can temporarily bind a CLA-derived metabolite.
- primary_references
- The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27923813/ · DOI 10.1074/jbc.M116.756288
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 342–348
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Biochemical kinetic and mass-spectrometric studies. · source_derived_draft · unverified_draft
## cla-gsh-adduct Glutathione can temporarily bind a CLA-derived metabolite. NO2-CLA reacted reversibly with glutathione and other low-molecular-weight thiols through electrophilic beta and delta carbons. Model: Biochemical kinetic and mass-spectrometric studies. Limitations: Adduct formation is not proof of systemic glutathione depletion. Evidence access: Primary abstract The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27923813/ · DOI 10.1074/jbc.M116.756288
Complete structured claim and evidence
What acts on it
CLA yielded substantially more nitration products than nonconjugated linoleic acid under the tested nitrogen-oxide reactions.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Chemical, cellular and in-vivo nitration experiments.
- limitations
- This is formation of a different molecule, not evidence that plain CLA has every nitro-lipid action.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Its double-bond arrangement changes its chemical reactivity.
- primary_references
- Conjugated linoleic acid is a preferential substrate for fatty acid nitration. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23144452/ · DOI 10.1074/jbc.M112.401356
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 310–316
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Chemical, cellular and in-vivo nitration experiments. · source_derived_draft · unverified_draft
## cla-nitration Its double-bond arrangement changes its chemical reactivity. CLA yielded substantially more nitration products than nonconjugated linoleic acid under the tested nitrogen-oxide reactions. Model: Chemical, cellular and in-vivo nitration experiments. Limitations: This is formation of a different molecule, not evidence that plain CLA has every nitro-lipid action. Evidence access: Primary abstract Conjugated linoleic acid is a preferential substrate for fatty acid nitration. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23144452/ · DOI 10.1074/jbc.M112.401356
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.