Component

Myeloid leukemia growth in the taurine niche experiments

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Exogenous taurine increased leukemia-cell colony formation and accelerated disease progression in the tested immunocompetent mouse leukemia model.

    Taurine → Myeloid leukemia growth in the taurine niche experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text, Extended Data Figure 5o–r and results
    experimental_model
    Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays.
    limitations
    Not a human trial or proof that taurine initiates leukemia in healthy people.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    Additional taurine worsened an existing malignancy in this experimental setting.
    primary_references
    Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 553–559

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays. · source_derived_draft · unverified_draft

    ## taurine-leukemia-supplement Additional taurine worsened an existing malignancy in this experimental setting. Exogenous taurine increased leukemia-cell colony formation and accelerated disease progression in the tested immunocompetent mouse leukemia model. Model: Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays. Limitations: Not a human trial or proof that taurine initiates leukemia in healthy people. Evidence access: Primary full text, Extended Data Figure 5o–r and results Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
    Complete structured claim and evidence

  2. Genetic loss of Slc6a6 impaired progression in mouse myeloid leukemia models.

    Mouse taurine transporter / Slc6a6 → Myeloid leukemia growth in the taurine niche experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse loss-of-function and in-vivo leukemia experiments.
    limitations
    This does not negate taurine requirements of normal retina and heart.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    Leukemia cells needed taurine uptake in these models.
    primary_references
    Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 529–535

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse loss-of-function and in-vivo leukemia experiments. · source_derived_draft · unverified_draft

    ## taurine-leukemia-taut-loss Leukemia cells needed taurine uptake in these models. Genetic loss of Slc6a6 impaired progression in mouse myeloid leukemia models. Model: Mouse loss-of-function and in-vivo leukemia experiments. Limitations: This does not negate taurine requirements of normal retina and heart. Evidence access: Primary abstract Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
    Complete structured claim and evidence

  3. Deleting Cdo1 in mouse mesenchymal/osteolineage cells reduced support for leukemia growth and prolonged survival in the transplanted leukemia model.

    Mouse cysteine dioxygenase / Cdo1 → Myeloid leukemia growth in the taurine niche experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text, Figure 2 and niche experiments
    experimental_model
    Conditional mouse Cdo1 deletion, coculture and leukemia transplantation.
    limitations
    An established leukemia model does not measure cancer incidence in healthy supplement users.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    The tumor-supporting tissue supplied taurine to leukemia cells.
    primary_references
    Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 513–519

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Conditional mouse Cdo1 deletion, coculture and leukemia transplantation. · source_derived_draft · unverified_draft

    ## taurine-niche-mouse-cdo1 The tumor-supporting tissue supplied taurine to leukemia cells. Deleting Cdo1 in mouse mesenchymal/osteolineage cells reduced support for leukemia growth and prolonged survival in the transplanted leukemia model. Model: Conditional mouse Cdo1 deletion, coculture and leukemia transplantation. Limitations: An established leukemia model does not measure cancer incidence in healthy supplement users. Evidence access: Primary full text, Figure 2 and niche experiments Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards