{"id":"c6d0c07a-1aa3-5da8-8728-fb9273df33ff","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-taut-loss","predicate":"loss_reduces","statement":"Genetic loss of Slc6a6 impaired progression in mouse myeloid leukemia models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b49570aa-cba7-5475-b8a7-d627e3f6f45f","mechanism_event_label":"Leukemia cells needed taurine uptake in these models.","subject":{"id":"97bfec84-f327-5208-8983-71138dd03b45","slug":"mouse-slc6a6","display_name":"Mouse taurine transporter / Slc6a6","entity_type_key":"protein"},"object":{"id":"2a43d687-fc0c-54ae-bdad-38f5e9ef03dc","slug":"mouse-taurine-leukemia-growth","display_name":"Myeloid leukemia growth in the taurine niche experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b49570aa-cba7-5475-b8a7-d627e3f6f45f","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-taut-loss-event","event_type":"observed_relationship","label":"Leukemia cells needed taurine uptake in these models.","description":"Genetic loss of Slc6a6 impaired progression in mouse myeloid leukemia models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97bfec84-f327-5208-8983-71138dd03b45","slug":"mouse-slc6a6","display_name":"Mouse taurine transporter / Slc6a6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a43d687-fc0c-54ae-bdad-38f5e9ef03dc","slug":"mouse-taurine-leukemia-growth","display_name":"Myeloid leukemia growth in the taurine niche experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse loss-of-function and in-vivo leukemia experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not negate taurine requirements of normal retina and heart.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Leukemia cells needed taurine uptake in these models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c127ba1d-a3d3-55eb-a4ce-a23fb82e7b01","evidence_kind":"source_excerpt","locator":"Lines 529-535","start_line":529,"end_line":535,"excerpt":"## taurine-leukemia-taut-loss\nLeukemia cells needed taurine uptake in these models.\nGenetic loss of Slc6a6 impaired progression in mouse myeloid leukemia models.\nModel: Mouse loss-of-function and in-vivo leukemia experiments.\nLimitations: This does not negate taurine requirements of normal retina and heart.\nEvidence access: Primary abstract\nTaurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","model_system":"Mouse loss-of-function and in-vivo leukemia experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}