{"id":"4b9df55d-914e-51c0-9dde-bdaf8be689c6","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-supplement","predicate":"supplementation_accelerates","statement":"Exogenous taurine increased leukemia-cell colony formation and accelerated disease progression in the tested immunocompetent mouse leukemia model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5a4dbfaf-4536-57f5-8f1b-325dda8f5b3a","mechanism_event_label":"Additional taurine worsened an existing malignancy in this experimental setting.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"2a43d687-fc0c-54ae-bdad-38f5e9ef03dc","slug":"mouse-taurine-leukemia-growth","display_name":"Myeloid leukemia growth in the taurine niche experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5a4dbfaf-4536-57f5-8f1b-325dda8f5b3a","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-supplement-event","event_type":"observed_relationship","label":"Additional taurine worsened an existing malignancy in this experimental setting.","description":"Exogenous taurine increased leukemia-cell colony formation and accelerated disease progression in the tested immunocompetent mouse leukemia model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a43d687-fc0c-54ae-bdad-38f5e9ef03dc","slug":"mouse-taurine-leukemia-growth","display_name":"Myeloid leukemia growth in the taurine niche experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, Extended Data Figure 5o–r and results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human trial or proof that taurine initiates leukemia in healthy people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Additional taurine worsened an existing malignancy in this experimental setting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c57c3489-4330-5f8a-87a0-d887dbdeccec","evidence_kind":"source_excerpt","locator":"Lines 553-559","start_line":553,"end_line":559,"excerpt":"## taurine-leukemia-supplement\nAdditional taurine worsened an existing malignancy in this experimental setting.\nExogenous taurine increased leukemia-cell colony formation and accelerated disease progression in the tested immunocompetent mouse leukemia model.\nModel: Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays.\nLimitations: Not a human trial or proof that taurine initiates leukemia in healthy people.\nEvidence access: Primary full text, Extended Data Figure 5o–r and results\nTaurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","model_system":"Mouse leukemia supplementation experiments, with separate patient-derived cell colony assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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