Component
Iron-loaded mouse Sod2
Mouse Sod2 incorporating iron in dietary experiments.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After four weeks on the iron-enriched diet, nearly 80% of isolated mouse liver Sod2 was iron-loaded.
Experimental context and source evidence
- cross_nutrient
- Iron excess altered occupancy of a Mn enzyme.
- experimental_model
- Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments
- exposure
- Five-week-old male C57BL/6J mice; 2700 ppm Fe and 150 ppm Mn versus control 275 ppm Fe and 150 ppm Mn, four weeks.
- limitations
- Experimental iron excess, not iron deficiency or a human oral-dose equivalence.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- A high-iron mouse diet shifted Sod2 toward iron loading.
- primary_references
- [mn-enz-29398562] Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. (2018). https://pubmed.ncbi.nlm.nih.gov/29398562/ DOI: 10.1016/j.chembiol.2018.01.007
- tissue_or_cell_type
- Liver Sod2
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 521–532
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments · source_derived_draft · unverified_draft
### mn-enz-mouse-high-fe-iron-sod2 After four weeks on the iron-enriched diet, nearly 80% of isolated mouse liver Sod2 was iron-loaded. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: A high-iron mouse diet shifted Sod2 toward iron loading. organism: Mus musculus tissue_or_cell_type: Liver Sod2 experimental_model: Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments limitations: Experimental iron excess, not iron deficiency or a human oral-dose equivalence. exposure: Five-week-old male C57BL/6J mice; 2700 ppm Fe and 150 ppm Mn versus control 275 ppm Fe and 150 ppm Mn, four weeks. cross_nutrient: Iron excess altered occupancy of a Mn enzyme. [mn-enz-29398562] Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. (2018). https://pubmed.ncbi.nlm.nih.gov/29398562/ DOI: 10.1016/j.chembiol.2018.01.007
Complete structured claim and evidenceMice fed the lower-manganese diet for four weeks had approximately 30% of isolated liver Sod2 iron-loaded, versus negligible iron loading in controls.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Dietary Mn:Fe balance affected mouse Sod2 metal occupancy.
- experimental_model
- Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments
- exposure
- Four weeks of 40 ppm Mn/275 ppm Fe versus 150 ppm Mn/275 ppm Fe control.
- limitations
- Primary experimental scope only; no human dietary threshold, clinical treatment rule, or universal metal substitution is established.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- Lower dietary manganese relative to iron changed liver Sod2 metal loading in mice.
- primary_references
- [mn-enz-29398562] Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. (2018). https://pubmed.ncbi.nlm.nih.gov/29398562/ DOI: 10.1016/j.chembiol.2018.01.007
- tissue_or_cell_type
- Liver Sod2
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 508–519
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments · source_derived_draft · unverified_draft
### mn-enz-mouse-low-mn-iron-sod2 Mice fed the lower-manganese diet for four weeks had approximately 30% of isolated liver Sod2 iron-loaded, versus negligible iron loading in controls. Condition category: nutrient_deficiency nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lower dietary manganese relative to iron changed liver Sod2 metal loading in mice. organism: Mus musculus tissue_or_cell_type: Liver Sod2 experimental_model: Purified SOD2, SOD2-overexpressing human cells, and dietary C57BL/6J mouse experiments limitations: Primary experimental scope only; no human dietary threshold, clinical treatment rule, or universal metal substitution is established. exposure: Four weeks of 40 ppm Mn/275 ppm Fe versus 150 ppm Mn/275 ppm Fe control. cross_nutrient: Dietary Mn:Fe balance affected mouse Sod2 metal occupancy. [mn-enz-29398562] Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. (2018). https://pubmed.ncbi.nlm.nih.gov/29398562/ DOI: 10.1016/j.chembiol.2018.01.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.