Component
Mouse retinol-binding protein 4 / Rbp4
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
RBP-deficient mice supported an RBP-dependent mechanism for CLA-induced hepatic retinol secretion and redistribution toward adipose tissue.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- RBP-loss mouse comparison with t10,c12 supplementation.
- limitations
- Genetic model, not evidence that RBP abundance alone predicts a human response.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- A transport protein helped determine where vitamin A went.
- primary_references
- Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 262–268
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · RBP-loss mouse comparison with t10,c12 supplementation. · source_derived_draft · unverified_draft
## cla-rbp-loss A transport protein helped determine where vitamin A went. RBP-deficient mice supported an RBP-dependent mechanism for CLA-induced hepatic retinol secretion and redistribution toward adipose tissue. Model: RBP-loss mouse comparison with t10,c12 supplementation. Limitations: Genetic model, not evidence that RBP abundance alone predicts a human response. Evidence access: Primary abstract Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200
Complete structured claim and evidence
Where it participates (unsigned role)
Only the t10,c12 preparation increased hepatic retinol secretion and serum retinol/RBP.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse dietary comparison.
- limitations
- Retinoid oxidation was only proposed; no demonstrated human deficiency or toxicity.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Vitamin A distribution changed beyond liver storage.
- primary_references
- Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 254–260
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse dietary comparison. · source_derived_draft · unverified_draft
## cla-retinol-release Vitamin A distribution changed beyond liver storage. Only the t10,c12 preparation increased hepatic retinol secretion and serum retinol/RBP. Model: Mouse dietary comparison. Limitations: Retinoid oxidation was only proposed; no demonstrated human deficiency or toxicity. Evidence access: Primary abstract Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.