{"id":"c614b4b1-e954-597c-98a4-4100a102e842","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-rbp-loss","predicate":"loss_blocks_reported_redistribution","statement":"RBP-deficient mice supported an RBP-dependent mechanism for CLA-induced hepatic retinol secretion and redistribution toward adipose tissue.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d1c2b1bf-19d9-5903-8ad8-576682857d1c","mechanism_event_label":"A transport protein helped determine where vitamin A went.","subject":{"id":"934664f2-7b3b-5e57-9ed4-a748232903e3","slug":"mouse-rbp4","display_name":"Mouse retinol-binding protein 4 / Rbp4","entity_type_key":"protein"},"object":{"id":"8ef6a679-5ce7-5097-970e-c4876061af4e","slug":"mouse-retinoid-adipose-redistribution","display_name":"Mouse retinoid redistribution toward adipose tissue","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d1c2b1bf-19d9-5903-8ad8-576682857d1c","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-rbp-loss-event","event_type":"observed_relationship","label":"A transport protein helped determine where vitamin A went.","description":"RBP-deficient mice supported an RBP-dependent mechanism for CLA-induced hepatic retinol secretion and redistribution toward adipose tissue.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"934664f2-7b3b-5e57-9ed4-a748232903e3","slug":"mouse-rbp4","display_name":"Mouse retinol-binding protein 4 / Rbp4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8ef6a679-5ce7-5097-970e-c4876061af4e","slug":"mouse-retinoid-adipose-redistribution","display_name":"Mouse retinoid redistribution toward adipose tissue","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RBP-loss mouse comparison with t10,c12 supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic model, not evidence that RBP abundance alone predicts a human response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A transport protein helped determine where vitamin A went.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a2674b52-6c58-5833-ac0c-b8e90df3ce8e","evidence_kind":"source_excerpt","locator":"Lines 262-268","start_line":262,"end_line":268,"excerpt":"## cla-rbp-loss\nA transport protein helped determine where vitamin A went.\nRBP-deficient mice supported an RBP-dependent mechanism for CLA-induced hepatic retinol secretion and redistribution toward adipose tissue.\nModel: RBP-loss mouse comparison with t10,c12 supplementation.\nLimitations: Genetic model, not evidence that RBP abundance alone predicts a human response.\nEvidence access: Primary abstract\nHepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","model_system":"RBP-loss mouse comparison with t10,c12 supplementation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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