{"id":"36178a09-5445-50d3-99af-115d35fb47f0","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-retinol-release","predicate":"increases","statement":"Only the t10,c12 preparation increased hepatic retinol secretion and serum retinol/RBP.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1a7b2a31-a9e6-5a59-a61e-09256d78678d","mechanism_event_label":"Vitamin A distribution changed beyond liver storage.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"ff808a67-204a-5df4-95d5-3cbe049c51a9","slug":"mouse-hepatic-retinol-secretion","display_name":"Mouse hepatic retinol secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1a7b2a31-a9e6-5a59-a61e-09256d78678d","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-retinol-release-event","event_type":"observed_relationship","label":"Vitamin A distribution changed beyond liver storage.","description":"Only the t10,c12 preparation increased hepatic retinol secretion and serum retinol/RBP.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ff808a67-204a-5df4-95d5-3cbe049c51a9","slug":"mouse-hepatic-retinol-secretion","display_name":"Mouse hepatic retinol secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"934664f2-7b3b-5e57-9ed4-a748232903e3","slug":"mouse-rbp4","display_name":"Mouse retinol-binding protein 4 / Rbp4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse dietary comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Retinoid oxidation was only proposed; no demonstrated human deficiency or toxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Vitamin A distribution changed beyond liver storage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"144c3b0b-4357-5da8-999d-cd27a5ea27f8","evidence_kind":"source_excerpt","locator":"Lines 254-260","start_line":254,"end_line":260,"excerpt":"## cla-retinol-release\nVitamin A distribution changed beyond liver storage.\nOnly the t10,c12 preparation increased hepatic retinol secretion and serum retinol/RBP.\nModel: Mouse dietary comparison.\nLimitations: Retinoid oxidation was only proposed; no demonstrated human deficiency or toxicity.\nEvidence access: Primary abstract\nHepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","model_system":"Mouse dietary comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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