Component

Mouse NFATc1

Context-specific entity; species, compartment and exposure are stated on each claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Cyclosporin A or FK506 blocked ranelate-associated NFATc1 activation and blunted osteoblast replication and phenotypic gene expression.

    Mouse calcineurin phosphatase complex → Mouse NFATc1 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast inhibitor experiments.
    limitations
    These inhibitors have broader biological effects; not a clinical interaction estimate.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    perturbation_agent
    inhibits · Cyclosporine A / ciclosporin A Cyclosporin A or FK506 blocked ranelate-associated NFATc1 activation; the experiment used cyclosporin A as the calcineurin blocker. FK506 is the second agent and is not a ledger entity yet.
    plain_language
    Blocking the activating phosphatase interrupts the downstream response.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 126–132

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast inhibitor experiments. · source_derived_draft · unverified_draft

    ## strontium-calcineurin-block Blocking the activating phosphatase interrupts the downstream response. Cyclosporin A or FK506 blocked ranelate-associated NFATc1 activation and blunted osteoblast replication and phenotypic gene expression. Model: Murine osteoblast inhibitor experiments. Limitations: These inhibitors have broader biological effects; not a clinical interaction estimate. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

  2. The strontium-ranelate study found NFATc1 nuclear translocation and increased transcriptional activity in murine MC3T3-E1 and primary osteoblasts.

    Strontium ranelate → Mouse NFATc1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast nuclear-localization and reporter assays.
    limitations
    Cell-culture preparation and model; not direct human target engagement.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    A calcium-responsive transcription factor connects exposure to gene regulation.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 118–124

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast nuclear-localization and reporter assays. · source_derived_draft · unverified_draft

    ## strontium-nfat-activation A calcium-responsive transcription factor connects exposure to gene regulation. The strontium-ranelate study found NFATc1 nuclear translocation and increased transcriptional activity in murine MC3T3-E1 and primary osteoblasts. Model: Murine osteoblast nuclear-localization and reporter assays. Limitations: Cell-culture preparation and model; not direct human target engagement. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Butyrate and propionate shifted osteoclast metabolism toward glycolysis, reduced Traf6/Nfatc1 expression and suppressed osteoclast differentiation in the reported experiments.

    Butyrate → Mouse osteoclast differentiation after butyrate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse osteoclast cultures and bone-loss interventions.
    limitations
    Distinct from the Treg/Wnt10b bone-formation study; neither proves a universal change in all bone cells.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    A separate pathway reduced bone breakdown rather than increasing bone building.
    primary_references
    Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29302038/ · DOI 10.1038/s41467-017-02490-4

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 478–484

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse osteoclast cultures and bone-loss interventions. · source_derived_draft · unverified_draft

    ## butyrate-osteoclast-metabolism A separate pathway reduced bone breakdown rather than increasing bone building. Butyrate and propionate shifted osteoclast metabolism toward glycolysis, reduced Traf6/Nfatc1 expression and suppressed osteoclast differentiation in the reported experiments. Model: Mouse osteoclast cultures and bone-loss interventions. Limitations: Distinct from the Treg/Wnt10b bone-formation study; neither proves a universal change in all bone cells. Evidence access: Primary abstract Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29302038/ · DOI 10.1038/s41467-017-02490-4
    Complete structured claim and evidence

  2. Strontium ranelate increased WNT3A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase.

    Strontium ranelate → Mouse Wnt3a source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast gene-expression experiments.
    limitations
    Expression is not equivalent to ligand delivery in human bone.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    One signaling response changes the production of another signaling protein.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 134–140

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast gene-expression experiments. · source_derived_draft · unverified_draft

    ## strontium-wnt3a-expression One signaling response changes the production of another signaling protein. Strontium ranelate increased WNT3A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase. Model: Murine osteoblast gene-expression experiments. Limitations: Expression is not equivalent to ligand delivery in human bone. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

  3. Strontium ranelate increased WNT5A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase.

    Strontium ranelate → Mouse Wnt5a source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast gene-expression experiments.
    limitations
    Expression is not equivalent to ligand delivery in human bone.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    One signaling response changes the production of another signaling protein.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 142–148

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast gene-expression experiments. · source_derived_draft · unverified_draft

    ## strontium-wnt5a-expression One signaling response changes the production of another signaling protein. Strontium ranelate increased WNT5A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase. Model: Murine osteoblast gene-expression experiments. Limitations: Expression is not equivalent to ligand delivery in human bone. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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