Component

Mouse Wnt5a

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Strontium ranelate increased WNT5A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase.

    Strontium ranelate → Mouse Wnt5a source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast gene-expression experiments.
    limitations
    Expression is not equivalent to ligand delivery in human bone.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    One signaling response changes the production of another signaling protein.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 142–148

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast gene-expression experiments. · source_derived_draft · unverified_draft

    ## strontium-wnt5a-expression One signaling response changes the production of another signaling protein. Strontium ranelate increased WNT5A expression in the murine osteoblast study; calcineurin inhibitors abolished the increase. Model: Murine osteoblast gene-expression experiments. Limitations: Expression is not equivalent to ligand delivery in human bone. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Knocking down RHOA abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study.

    Mouse RhoA → Strontium-associated osteoblast gene expression in mouse cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast knockdown experiments.
    limitations
    This establishes experimental dependency, not human dietary deficiency.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    A noncanonical Wnt component is another required step in this model.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 166–172

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast knockdown experiments. · source_derived_draft · unverified_draft

    ## strontium-rhoa-loss A noncanonical Wnt component is another required step in this model. Knocking down RHOA abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study. Model: Murine osteoblast knockdown experiments. Limitations: This establishes experimental dependency, not human dietary deficiency. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

  2. Knocking down RYK abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study.

    Mouse Ryk → Strontium-associated osteoblast gene expression in mouse cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast knockdown experiments.
    limitations
    This establishes experimental dependency, not human dietary deficiency.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    A noncanonical Wnt component is another required step in this model.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 158–164

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast knockdown experiments. · source_derived_draft · unverified_draft

    ## strontium-ryk-loss A noncanonical Wnt component is another required step in this model. Knocking down RYK abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study. Model: Murine osteoblast knockdown experiments. Limitations: This establishes experimental dependency, not human dietary deficiency. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

  3. The Wnt antagonists sFRP1 and DKK1 abolished ranelate-induced osteoblast gene expression in the murine cultures.

    sFRP1/DKK1 Wnt-antagonist experiments in mouse osteoblasts → Strontium-associated osteoblast gene expression in mouse cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Murine osteoblast Wnt-inhibition experiments.
    limitations
    The assay does not establish the same degree of dependence for all Wnt ligands or human tissues.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    Interrupting Wnt signaling removed the gene response.
    primary_references
    Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 150–156

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine osteoblast Wnt-inhibition experiments. · source_derived_draft · unverified_draft

    ## strontium-wnt-antagonists Interrupting Wnt signaling removed the gene response. The Wnt antagonists sFRP1 and DKK1 abolished ranelate-induced osteoblast gene expression in the murine cultures. Model: Murine osteoblast Wnt-inhibition experiments. Limitations: The assay does not establish the same degree of dependence for all Wnt ligands or human tissues. Evidence access: Primary abstract Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20554534/ · DOI 10.1074/jbc.M110.110502
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards