{"id":"34f94c9c-b3fe-5001-b136-8227c3450ef0","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rhoa-loss","predicate":"knockdown_abrogates","statement":"Knocking down RHOA abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e610f225-746d-51bb-bfdc-3e1a158ca06e","mechanism_event_label":"A noncanonical Wnt component is another required step in this model.","subject":{"id":"624993a2-950e-5fcd-a215-5e16e1c4f891","slug":"mouse-rhoa","display_name":"Mouse RhoA","entity_type_key":"protein"},"object":{"id":"9c225313-4278-5793-87af-401ce67579eb","slug":"mouse-strontium-osteoblast-gene-expression","display_name":"Strontium-associated osteoblast gene expression in mouse cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e610f225-746d-51bb-bfdc-3e1a158ca06e","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rhoa-loss-event","event_type":"observed_relationship","label":"A noncanonical Wnt component is another required step in this model.","description":"Knocking down RHOA abrogated strontium-ranelate-induced cell proliferation and osteoblast gene expression in the murine study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624993a2-950e-5fcd-a215-5e16e1c4f891","slug":"mouse-rhoa","display_name":"Mouse RhoA","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c225313-4278-5793-87af-401ce67579eb","slug":"mouse-strontium-osteoblast-gene-expression","display_name":"Strontium-associated osteoblast gene expression in mouse cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7e74ffe9-57d9-5504-98a8-5f5e6363159b","slug":"mouse-wnt5a","display_name":"Mouse Wnt5a","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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