Component

Mouse cerebral infarct size after focal ischemia

Mouse cerebral infarct size after focal ischemia. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Bicuculline prevented theanine-associated protection in the mouse ischemia model.

    Mouse GABA-A receptors, subunits unresolved → Mouse cerebral infarct size after focal ischemia source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"}
    experimental_model
    Focal cerebral ischemia and pharmacological pathway blockade
    exposure
    Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid
    limitations
    Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Mice
    plain_language
    The receptor mattered to this response, but the experiment did not establish direct receptor agonism.
    primary_references
    [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    tissue_or_cell_type
    Cerebral infarct size at 24 hours
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 445–456

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischemia and pharmacological pathway blockade · source_derived_draft · unverified_draft

    ### theanine-gaba-a-blockade Bicuculline prevented theanine-associated protection in the mouse ischemia model. Condition category: machinery_impairment nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor mattered to this response, but the experiment did not establish direct receptor agonism. organism: Mice tissue_or_cell_type: Cerebral infarct size at 24 hours experimental_model: Focal cerebral ischemia and pharmacological pathway blockade limitations: Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors. exposure: Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid evidence_span: {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"} [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    Complete structured claim and evidence

  2. The glutamate-decarboxylase inhibitor did not prevent theanine protection in the tested mouse model.

    3-Mercaptopropionic acid → Mouse cerebral infarct size after focal ischemia source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"}
    experimental_model
    Focal cerebral ischemia and pharmacological pathway blockade
    exposure
    Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid
    limitations
    Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Mice
    plain_language
    Receptor dependence cannot be simplified to proof that newly synthesized GABA caused the effect.
    primary_references
    [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    tissue_or_cell_type
    Cerebral infarct size at 24 hours

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 458–469

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischemia and pharmacological pathway blockade · source_derived_draft · unverified_draft

    ### theanine-gad-inhibitor-null The glutamate-decarboxylase inhibitor did not prevent theanine protection in the tested mouse model. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Receptor dependence cannot be simplified to proof that newly synthesized GABA caused the effect. organism: Mice tissue_or_cell_type: Cerebral infarct size at 24 hours experimental_model: Focal cerebral ischemia and pharmacological pathway blockade limitations: Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors. exposure: Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid evidence_span: {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"} [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    Complete structured claim and evidence

  3. Theanine reduced infarct size after focal cerebral ischemia in mice.

    L-Theanine → Mouse cerebral infarct size after focal ischemia source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"}
    experimental_model
    Focal cerebral ischemia and pharmacological pathway blockade
    exposure
    Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid
    limitations
    Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Mice
    plain_language
    This is an experimental injury outcome, not a demonstrated stroke treatment.
    primary_references
    [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    tissue_or_cell_type
    Cerebral infarct size at 24 hours

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 432–443

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischemia and pharmacological pathway blockade · source_derived_draft · unverified_draft

    ### theanine-ischemia-protection Theanine reduced infarct size after focal cerebral ischemia in mice. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This is an experimental injury outcome, not a demonstrated stroke treatment. organism: Mice tissue_or_cell_type: Cerebral infarct size at 24 hours experimental_model: Focal cerebral ischemia and pharmacological pathway blockade limitations: Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors. exposure: Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid evidence_span: {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"} [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
    Complete structured claim and evidence

  4. Carnosine treatment reduced infarct size in both wild-type and histidine-decarboxylase-null mice after permanent MCAO.

    L-Carnosine / beta-alanyl-L-histidine → Mouse cerebral infarct size after focal ischemia source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse cerebral ischemia with Hdc knockout.
    limitations
    Preclinical intervention; not stroke treatment guidance.
    nutrient_topic
    Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnosine / beta-alanyl-L-histidine
    plain_language
    Protection in this model did not require histamine synthesis.
    primary_references
    Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20043985/ · DOI 10.1016/j.freeradbiomed.2009.12.021

    Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19) · lines 460–466

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse cerebral ischemia with Hdc knockout. · source_derived_draft · unverified_draft

    ## carnosine-ischemia-hdc Protection in this model did not require histamine synthesis. Carnosine treatment reduced infarct size in both wild-type and histidine-decarboxylase-null mice after permanent MCAO. Model: Mouse cerebral ischemia with Hdc knockout. Limitations: Preclinical intervention; not stroke treatment guidance. Evidence access: Primary abstract Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20043985/ · DOI 10.1016/j.freeradbiomed.2009.12.021
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards