Component

Mouse deoxyhypusine synthase / Dhps

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Acute inhibition of hypusination impaired alternative macrophage activation while largely sparing glycolysis-associated classical activation.

    Mouse deoxyhypusine synthase / Dhps → Mouse IL-4-associated macrophage activation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse macrophage in-vitro and in-vivo models.
    limitations
    Alternative activation is not universally beneficial or equivalent to lower inflammation in every disease.
    nutrient_topic
    Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
    plain_language
    The same pathway affects immune states differently.
    primary_references
    Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31130465/ · DOI 10.1016/j.cmet.2019.05.003
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 294–300

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse macrophage in-vitro and in-vivo models. · source_derived_draft · unverified_draft

    ## spermidine-alternative-macrophage The same pathway affects immune states differently. Acute inhibition of hypusination impaired alternative macrophage activation while largely sparing glycolysis-associated classical activation. Model: Mouse macrophage in-vitro and in-vivo models. Limitations: Alternative activation is not universally beneficial or equivalent to lower inflammation in every disease. Evidence access: Primary full text Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31130465/ · DOI 10.1016/j.cmet.2019.05.003
    Complete structured claim and evidence

  2. GC7 inhibition of hypusination reduced oxidative phosphorylation in IL-4-activated mouse macrophages.

    Mouse deoxyhypusine synthase / Dhps → Mouse macrophage oxidative phosphorylation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse bone-marrow-derived macrophages; 10 micromolar GC7 for 24 hours in the tracing experiment.
    limitations
    GC7 can have off-target effects; accompanying genetic experiments strengthen but do not make every effect specific.
    nutrient_topic
    Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
    plain_language
    Blocking the translation pathway changes fuel use.
    primary_references
    Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31130465/ · DOI 10.1016/j.cmet.2019.05.003
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 262–268

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse bone-marrow-derived macrophages; 10 micromolar GC7 for 24 hours in the tracing experiment. · source_derived_draft · unverified_draft

    ## spermidine-macrophage-respiration Blocking the translation pathway changes fuel use. GC7 inhibition of hypusination reduced oxidative phosphorylation in IL-4-activated mouse macrophages. Model: Mouse bone-marrow-derived macrophages; 10 micromolar GC7 for 24 hours in the tracing experiment. Limitations: GC7 can have off-target effects; accompanying genetic experiments strengthen but do not make every effect specific. Evidence access: Primary full text Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31130465/ · DOI 10.1016/j.cmet.2019.05.003
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Disrupting eIF5A hypusination reduced nascent TFEB synthesis in the B-cell/autophagy study.

    Mouse eIF5A translation factor → Mouse transcription factor EB / Tfeb source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Mouse cellular experiments with translation labeling and hypusination perturbation.
    limitations
    Requirement is transcript- and context-dependent, not equal enhancement of all proteins.
    nutrient_topic
    Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
    plain_language
    Spermidine helps produce a regulator of cellular recycling.
    primary_references
    Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005

    Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 214–220

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse cellular experiments with translation labeling and hypusination perturbation. · source_derived_draft · unverified_draft

    ## spermidine-tfeb-translation Spermidine helps produce a regulator of cellular recycling. Disrupting eIF5A hypusination reduced nascent TFEB synthesis in the B-cell/autophagy study. Model: Mouse cellular experiments with translation labeling and hypusination perturbation. Limitations: Requirement is transcript- and context-dependent, not equal enhancement of all proteins. Evidence access: Primary full text Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards