Component
Mouse transcription factor EB / Tfeb
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Replacing the TFEB PPP motif with AAA partially rescued TFEB expression during GC7 treatment.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Murine TFEB constructs in NIH 3T3 cells.
- limitations
- Partial rescue; free proline supplementation was not tested.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- A sequence within the protein helps explain the dependency.
- primary_references
- Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 222–228
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Murine TFEB constructs in NIH 3T3 cells. · source_derived_draft · unverified_draft
## spermidine-tfeb-proline A sequence within the protein helps explain the dependency. Replacing the TFEB PPP motif with AAA partially rescued TFEB expression during GC7 treatment. Model: Murine TFEB constructs in NIH 3T3 cells. Limitations: Partial rescue; free proline supplementation was not tested. Evidence access: Primary full text Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005
Complete structured claim and evidenceDisrupting eIF5A hypusination reduced nascent TFEB synthesis in the B-cell/autophagy study.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Mouse cellular experiments with translation labeling and hypusination perturbation.
- limitations
- Requirement is transcript- and context-dependent, not equal enhancement of all proteins.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- Spermidine helps produce a regulator of cellular recycling.
- primary_references
- Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 214–220
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse cellular experiments with translation labeling and hypusination perturbation. · source_derived_draft · unverified_draft
## spermidine-tfeb-translation Spermidine helps produce a regulator of cellular recycling. Disrupting eIF5A hypusination reduced nascent TFEB synthesis in the B-cell/autophagy study. Model: Mouse cellular experiments with translation labeling and hypusination perturbation. Limitations: Requirement is transcript- and context-dependent, not equal enhancement of all proteins. Evidence access: Primary full text Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31474573/ · DOI 10.1016/j.molcel.2019.08.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.