Mouse duodenal cytochrome b / Cybrd1: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Cybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes.
Mouse duodenal cytochrome b / Cybrd1 → Blood iron-status markers source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/iron-research/15961514.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d", "start_char": 0, "end_char": 621, "text_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d"}
experimental_model
Gene inactivation and iron-status measurements
exposure
Normal and iron-deficient conditions
limitations
A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans.
nutrient_topic
Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
organism
Cybrd1-null mice
plain_language
A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.
primary_references
[iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716
tissue_or_cell_type
Whole-body and tissue iron stores
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1057–1068
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Gene inactivation and iron-status measurements · source_derived_draft · unverified_draft
### iron-dcytb-compensation Cybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption. organism: Cybrd1-null mice tissue_or_cell_type: Whole-body and tissue iron stores experimental_model: Gene inactivation and iron-status measurements limitations: A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans. exposure: Normal and iron-deficient conditions evidence_span: {"source_cache": "artifacts/iron-research/15961514.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d", "start_char": 0, "end_char": 621, "text_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d"} [iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716
Complete structured claim and evidence
Duodenal Cybrd1 expression induced ferric reductase activity in oocytes and cultured cells and localized to the enterocyte brush border.
Mouse duodenal cytochrome b / Cybrd1 → Intestinal ferric-to-ferrous iron reduction source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/iron-research/11230685.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32", "start_char": 0, "end_char": 824, "text_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32"}
experimental_model
Transporter/reductase discovery and expression assays
exposure
Cybrd1 expression and physiological modulation of iron absorption
limitations
Shows ferric reductase activity; not proof that this is the only reductase or universally indispensable in vivo.
nutrient_topic
Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
organism
Mouse Cybrd1 expressed in Xenopus oocytes and cultured cells
plain_language
Before nonheme iron enters through the ferrous-iron transporter, an enzyme can help convert it to the required chemical form.
primary_references
[iron-p11230685] An iron-regulated ferric reductase associated with the absorption of dietary iron. (2001). https://pubmed.ncbi.nlm.nih.gov/11230685/ DOI: 10.1126/science.1057206
tissue_or_cell_type
Duodenal brush border and expression systems
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 381–392
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter/reductase discovery and expression assays · source_derived_draft · unverified_draft
### iron-dcytb-reduction Duodenal Cybrd1 expression induced ferric reductase activity in oocytes and cultured cells and localized to the enterocyte brush border. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Before nonheme iron enters through the ferrous-iron transporter, an enzyme can help convert it to the required chemical form. organism: Mouse Cybrd1 expressed in Xenopus oocytes and cultured cells tissue_or_cell_type: Duodenal brush border and expression systems experimental_model: Transporter/reductase discovery and expression assays limitations: Shows ferric reductase activity; not proof that this is the only reductase or universally indispensable in vivo. exposure: Cybrd1 expression and physiological modulation of iron absorption evidence_span: {"source_cache": "artifacts/iron-research/11230685.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32", "start_char": 0, "end_char": 824, "text_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32"} [iron-p11230685] An iron-regulated ferric reductase associated with the absorption of dietary iron. (2001). https://pubmed.ncbi.nlm.nih.gov/11230685/ DOI: 10.1126/science.1057206
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Mouse duodenal cytochrome b / Cybrd1