{"id":"b4b463a1-ebad-5f13-906f-4a9624d6a149","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-dcytb-compensation","predicate":"loss_had_little_effect_on","statement":"Cybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"23c9d0cd-edb0-5206-b9d3-ce8d036b92a8","mechanism_event_label":"A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.","subject":{"id":"25f9c5ef-7bc2-58a0-8794-051dbe0a7851","slug":"mouse-cybrd1","display_name":"Mouse duodenal cytochrome b / Cybrd1","entity_type_key":"protein"},"object":{"id":"9f913706-8e9a-553a-ac67-0e406e504c60","slug":"iron-status-biomarkers","display_name":"Blood iron-status markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"23c9d0cd-edb0-5206-b9d3-ce8d036b92a8","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-dcytb-compensation-event","event_type":"biochemical_relationship","label":"A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.","description":"Cybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"25f9c5ef-7bc2-58a0-8794-051dbe0a7851","slug":"mouse-cybrd1","display_name":"Mouse duodenal cytochrome b / Cybrd1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f913706-8e9a-553a-ac67-0e406e504c60","slug":"iron-status-biomarkers","display_name":"Blood iron-status markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/15961514.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d\", \"start_char\": 0, \"end_char\": 621, \"text_sha256\": \"82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Gene inactivation and iron-status measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Normal and iron-deficient conditions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Cybrd1-null mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body and tissue iron stores","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9c8d8b89-298d-511a-9a2c-bce826f42d53","evidence_kind":"source_excerpt","locator":"Lines 1057-1068","start_line":1057,"end_line":1068,"excerpt":"### iron-dcytb-compensation\nCybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.\norganism: Cybrd1-null mice\ntissue_or_cell_type: Whole-body and tissue iron stores\nexperimental_model: Gene inactivation and iron-status measurements\nlimitations: A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans.\nexposure: Normal and iron-deficient conditions\nevidence_span: {\"source_cache\": \"artifacts/iron-research/15961514.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d\", \"start_char\": 0, \"end_char\": 621, \"text_sha256\": \"82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d\"}\n[iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716","model_system":"Gene inactivation and iron-status measurements","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1560864c-91d1-58dc-90c4-49bf61aba3de","stable_key":"import-e13b03e1-a614-543a-ac1b-97df18cfe30d","title":"Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f9dab767a21c9bbfef3227707fe3c82953536bb1335599dd4ef93b5ea2dbf03f","revision_id":"77700d7f-2902-54b9-adae-8cbc77b24682","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}