Component
Blood iron-status markers
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
One year of calcium supplementation did not significantly alter measured iron-status markers in adolescent girls.
Experimental context and source evidence
- experimental_model
- 113 girls, randomized double-blind placebo-controlled trial.
- exposure
- 500 mg calcium/day with evening meal for one year; reported marker comparisons were nonsignificant.
- limitations
- Does not establish absence of effect in iron-deficient people; hemoglobin, ferritin and soluble transferrin receptor are distinct endpoints.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- No significant worsening of iron markers was found after a year of supplementation in these girls.
- primary_references
- [cal-clin-molgaard2005] Long-term calcium supplementation does not affect the iron status of 12-14-y-old girls (2005). https://pubmed.ncbi.nlm.nih.gov/16002806/ DOI: 10.1093/ajcn.82.1.98
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1434–1444
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 113 girls, randomized double-blind placebo-controlled trial. · source_derived_draft · unverified_draft
### cal-iron-status-longterm One year of calcium supplementation did not significantly alter measured iron-status markers in adolescent girls. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: No significant worsening of iron markers was found after a year of supplementation in these girls. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 113 girls, randomized double-blind placebo-controlled trial. limitations: Does not establish absence of effect in iron-deficient people; hemoglobin, ferritin and soluble transferrin receptor are distinct endpoints. exposure: 500 mg calcium/day with evening meal for one year; reported marker comparisons were nonsignificant. [cal-clin-molgaard2005] Long-term calcium supplementation does not affect the iron status of 12-14-y-old girls (2005). https://pubmed.ncbi.nlm.nih.gov/16002806/ DOI: 10.1093/ajcn.82.1.98
Complete structured claim and evidenceCybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/15961514.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d", "start_char": 0, "end_char": 621, "text_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d"}
- experimental_model
- Gene inactivation and iron-status measurements
- exposure
- Normal and iron-deficient conditions
- limitations
- A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Cybrd1-null mice
- plain_language
- A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption.
- primary_references
- [iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716
- tissue_or_cell_type
- Whole-body and tissue iron stores
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1057–1068
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Gene inactivation and iron-status measurements · source_derived_draft · unverified_draft
### iron-dcytb-compensation Cybrd1 deletion had little or no effect on mouse body iron stores even during iron deficiency, implying alternative reduction routes. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A real enzyme function does not mean that losing that enzyme always removes every route to iron absorption. organism: Cybrd1-null mice tissue_or_cell_type: Whole-body and tissue iron stores experimental_model: Gene inactivation and iron-status measurements limitations: A mouse compensation result; it does not negate Cybrd1 ferric-reductase activity or prove dispensability in humans. exposure: Normal and iron-deficient conditions evidence_span: {"source_cache": "artifacts/iron-research/15961514.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d", "start_char": 0, "end_char": 621, "text_sha256": "82665d0951ddf0b58240697d40ec2390474e6799bbeba29f132e57f562e5782d"} [iron-p15961514] Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15961514/ DOI: 10.1182/blood-2005-02-0716
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.