Component
Intestinal ferric-to-ferrous iron reduction
Intestinal ferric-to-ferrous iron reduction. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Duodenal Cybrd1 expression induced ferric reductase activity in oocytes and cultured cells and localized to the enterocyte brush border.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/11230685.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32", "start_char": 0, "end_char": 824, "text_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32"}
- experimental_model
- Transporter/reductase discovery and expression assays
- exposure
- Cybrd1 expression and physiological modulation of iron absorption
- limitations
- Shows ferric reductase activity; not proof that this is the only reductase or universally indispensable in vivo.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mouse Cybrd1 expressed in Xenopus oocytes and cultured cells
- plain_language
- Before nonheme iron enters through the ferrous-iron transporter, an enzyme can help convert it to the required chemical form.
- primary_references
- [iron-p11230685] An iron-regulated ferric reductase associated with the absorption of dietary iron. (2001). https://pubmed.ncbi.nlm.nih.gov/11230685/ DOI: 10.1126/science.1057206
- tissue_or_cell_type
- Duodenal brush border and expression systems
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 381–392
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter/reductase discovery and expression assays · source_derived_draft · unverified_draft
### iron-dcytb-reduction Duodenal Cybrd1 expression induced ferric reductase activity in oocytes and cultured cells and localized to the enterocyte brush border. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Before nonheme iron enters through the ferrous-iron transporter, an enzyme can help convert it to the required chemical form. organism: Mouse Cybrd1 expressed in Xenopus oocytes and cultured cells tissue_or_cell_type: Duodenal brush border and expression systems experimental_model: Transporter/reductase discovery and expression assays limitations: Shows ferric reductase activity; not proof that this is the only reductase or universally indispensable in vivo. exposure: Cybrd1 expression and physiological modulation of iron absorption evidence_span: {"source_cache": "artifacts/iron-research/11230685.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32", "start_char": 0, "end_char": 824, "text_sha256": "e3ef2e0a58c59707a044f0507c68aa61988718dfc97611b6664705468a5efa32"} [iron-p11230685] An iron-regulated ferric reductase associated with the absorption of dietary iron. (2001). https://pubmed.ncbi.nlm.nih.gov/11230685/ DOI: 10.1126/science.1057206
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.