Component

Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Cars2-derived cysteine persulfide/H2S signaling promoted EBF2 persulfidation and interaction with PPARgamma or BRG1, supporting thermogenic gene recruitment.

    Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2 → Mouse early B-cell factor 2 / Ebf2 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse-centered brown-adipocyte and in vivo experimental program.
    limitations
    Abstract does not fully resolve each chemical intermediate; do not equate free H2S, CysSSH and protein-bound persulfides.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    Sulfur chemistry fed back to the transcription machinery.
    primary_references
    Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 396–402

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse-centered brown-adipocyte and in vivo experimental program. · source_derived_draft · unverified_draft

    ## l-cysteine-cars2-ebf2-persulfidation Sulfur chemistry fed back to the transcription machinery. Cars2-derived cysteine persulfide/H2S signaling promoted EBF2 persulfidation and interaction with PPARgamma or BRG1, supporting thermogenic gene recruitment. Model: Mouse-centered brown-adipocyte and in vivo experimental program. Limitations: Abstract does not fully resolve each chemical intermediate; do not equate free H2S, CysSSH and protein-bound persulfides. Evidence access: Primary abstract Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690
    Complete structured claim and evidence

  2. Loss of Cars2 in thermogenic fat impaired brown-fat formation and reduced thermogenesis and energy expenditure in mice.

    Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2 → Brown-fat development and function in mouse Cars2 experiments source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Mouse thermogenic-fat Cars2 loss.
    limitations
    This is not the same intervention as Cth loss plus a cysteine-free diet.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    A tissue-specific enzyme defect produced a different response from whole-body nutrient withdrawal.
    primary_references
    Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 404–410

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse thermogenic-fat Cars2 loss. · source_derived_draft · unverified_draft

    ## l-cysteine-cars2-fat-loss A tissue-specific enzyme defect produced a different response from whole-body nutrient withdrawal. Loss of Cars2 in thermogenic fat impaired brown-fat formation and reduced thermogenesis and energy expenditure in mice. Model: Mouse thermogenic-fat Cars2 loss. Limitations: This is not the same intervention as Cth loss plus a cysteine-free diet. Evidence access: Primary abstract Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690
    Complete structured claim and evidence

What acts on it

  1. The study reported direct EBF2 induction of Cars2 during brown-adipocyte differentiation.

    Mouse early B-cell factor 2 / Ebf2 → Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse brown-fat study and cellular differentiation experiments.
    limitations
    Abstract-level extraction; detailed promoter occupancy and construct conditions require full-method review.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    A transcription factor increased the machinery for a sulfur-signaling pathway.
    primary_references
    Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 388–394

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse brown-fat study and cellular differentiation experiments. · source_derived_draft · unverified_draft

    ## l-cysteine-ebf2-cars2-expression A transcription factor increased the machinery for a sulfur-signaling pathway. The study reported direct EBF2 induction of Cars2 during brown-adipocyte differentiation. Model: Mouse brown-fat study and cellular differentiation experiments. Limitations: Abstract-level extraction; detailed promoter occupancy and construct conditions require full-method review. Evidence access: Primary abstract Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. PLP treatment or an H2S donor improved brown-adipocyte function and reduced obesity progression in the reported high-fat-fed mouse experiments.

    PLP → Brown-fat development and function in mouse Cars2 experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse high-fat-diet and brown-adipocyte experiments.
    limitations
    Abstract-only intervention details; no human dose, route equivalence or cysteine-plus-B6 synergy is established.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    A B6-derived coenzyme and a sulfur donor were separately tested inputs to this pathway.
    primary_references
    Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 412–418

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse high-fat-diet and brown-adipocyte experiments. · source_derived_draft · unverified_draft

    ## l-cysteine-cars2-plp-intervention A B6-derived coenzyme and a sulfur donor were separately tested inputs to this pathway. PLP treatment or an H2S donor improved brown-adipocyte function and reduced obesity progression in the reported high-fat-fed mouse experiments. Model: Mouse high-fat-diet and brown-adipocyte experiments. Limitations: Abstract-only intervention details; no human dose, route equivalence or cysteine-plus-B6 synergy is established. Evidence access: Primary abstract Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41849685/ · DOI 10.1002/advs.202522690
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards