{"id":"53b0101e-64e7-5573-8aed-dec28f218aa5","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-cars2-fat-loss","predicate":"supports","statement":"Loss of Cars2 in thermogenic fat impaired brown-fat formation and reduced thermogenesis and energy expenditure in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"35089766-7c44-524b-bc57-69def695b72b","mechanism_event_label":"A tissue-specific enzyme defect produced a different response from whole-body nutrient withdrawal.","subject":{"id":"9fe61578-bc3d-54ef-947a-4537a63d47ba","slug":"mouse-cars2","display_name":"Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2","entity_type_key":"protein"},"object":{"id":"b4551151-4548-5b96-ba40-da9dd46800b1","slug":"mouse-cars2-brown-fat-program","display_name":"Brown-fat development and function in mouse Cars2 experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"35089766-7c44-524b-bc57-69def695b72b","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-cars2-fat-loss-event","event_type":"observed_relationship","label":"A tissue-specific enzyme defect produced a different response from whole-body nutrient withdrawal.","description":"Loss of Cars2 in thermogenic fat impaired brown-fat formation and reduced thermogenesis and energy expenditure in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fe61578-bc3d-54ef-947a-4537a63d47ba","slug":"mouse-cars2","display_name":"Mouse mitochondrial cysteinyl-tRNA synthetase / Cars2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b4551151-4548-5b96-ba40-da9dd46800b1","slug":"mouse-cars2-brown-fat-program","display_name":"Brown-fat development and function in mouse Cars2 experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"104876de-8ff6-5cf1-940f-1ef80bfbe85e","slug":"mouse-ebf2","display_name":"Mouse early B-cell factor 2 / Ebf2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0685d7c6-76f8-5d43-9a11-e2fc8ab5f714","slug":"cysteine-persulfide","display_name":"Cysteine persulfide / CysSSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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