Component

O-Methylrosmarinic acid, site unresolved

O-Methylrosmarinic acid, site unresolved

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Porcine COMT with SAM generated a methylated RA standard used to identify methyl-RA.

    Porcine catechol O-methyltransferase → O-Methylrosmarinic acid, site unresolved Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Indexed primary abstract plus publisher-indexed Results describing the porcine COMT/SAM methylated standard. Full Methods access unavailable.
    experimental_model
    Commercial porcine liver COMT and SAM; publisher-indexed Results.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Rosmarinic acid collection; exact intervention and molecular form govern interpretation. · Rosmarinic acid
    plain_language
    Porcine COMT with SAM generated a methylated RA standard used to identify methyl-RA.
    primary_references
    Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor. | https://pubmed.ncbi.nlm.nih.gov/21779558/ | https://doi.org/10.1039/c0fo00070a
    source_locator
    Reviewed reference ra-comt-substrate; Demonstrates enzymatic methylation, not an in-vivo rate or pool depletion.

    Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026) · lines 105–111

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Commercial porcine liver COMT and SAM; publisher-indexed Results. · Recorded from source · Recorded from source

    ### ra-comt-substrate Porcine COMT with SAM generated a methylated RA standard used to identify methyl-RA. Demonstrates enzymatic methylation, not an in-vivo rate or pool depletion. Model and exposure: Commercial porcine liver COMT and SAM; publisher-indexed Results. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor. | 2011 | https://pubmed.ncbi.nlm.nih.gov/21779558/ | https://doi.org/10.1039/c0fo00070a | Access: Indexed primary abstract plus publisher-indexed Results describing the porcine COMT/SAM methylated standard. Full Methods access unavailable.
    Complete structured claim and evidence

  2. Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.

    RA-enriched Perilla frutescens extract → O-Methylrosmarinic acid, site unresolved Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Indexed primary abstract; publisher-linked erratum exists but its body was inaccessible. Corrected numerical details beyond the abstract are not verified.; Publisher identifies an erratum linked to the original paper. Correction body inaccessible; scope not independently verified.
    experimental_model
    Six men; placebo crossover, 10-day interval; LC-MS.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Rosmarinic acid collection; exact intervention and molecular form govern interpretation. · Rosmarinic acid
    plain_language
    Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.
    primary_references
    Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. | https://pubmed.ncbi.nlm.nih.gov/15309457/ | https://doi.org/10.1007/s00394-004-0482-2
    primary_references
    Erratum: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans | https://link.springer.com/article/10.1007/s00394-004-0524-9
    source_locator
    Reviewed reference ra-human-methyl-metabolite; Methyl-RA plasma Tmax 2 h; conjugated species predominated. Erratum body not recovered.

    Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026) · lines 51–58

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Six men; placebo crossover, 10-day interval; LC-MS. · Recorded from source · Recorded from source

    ### ra-human-methyl-metabolite Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA. Methyl-RA plasma Tmax 2 h; conjugated species predominated. Erratum body not recovered. Model and exposure: Six men; placebo crossover, 10-day interval; LC-MS. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. | 2005 | https://pubmed.ncbi.nlm.nih.gov/15309457/ | https://doi.org/10.1007/s00394-004-0482-2 | Access: Indexed primary abstract; publisher-linked erratum exists but its body was inaccessible. Corrected numerical details beyond the abstract are not verified. Reference: Erratum: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans | 2005 | https://link.springer.com/article/10.1007/s00394-004-0524-9 | Access: Publisher identifies an erratum linked to the original paper. Correction body inaccessible; scope not independently verified.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.