{"id":"71dc5335-fbf6-5626-bbe1-ce8d1369f500","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-human-methyl-metabolite","predicate":"reported_relationship","statement":"Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"c42361b2-9d03-5329-901c-fba014aa7e40","mechanism_event_label":"Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.","subject":{"id":"30ca7b15-db8f-5b8b-9dfc-62b04e915585","slug":"perilla-ra-enriched-extract","display_name":"RA-enriched Perilla frutescens extract","entity_type_key":"botanical"},"object":{"id":"a00c5b15-3afd-5b6b-b817-a3f78f6ca3cd","slug":"methyl-rosmarinic-acid","display_name":"O-Methylrosmarinic acid, site unresolved","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"c42361b2-9d03-5329-901c-fba014aa7e40","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-human-methyl-metabolite-event","event_type":"experimental_observation","label":"Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.","description":"### ra-human-methyl-metabolite\n\nMethylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.\nMethyl-RA plasma Tmax 2 h; conjugated species predominated. Erratum body not recovered.\nModel and exposure: Six men; placebo crossover, 10-day interval; LC-MS.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. | 2005 | https://pubmed.ncbi.nlm.nih.gov/15309457/ | https://doi.org/10.1007/s00394-004-0482-2 | Access: Indexed primary abstract; publisher-linked erratum exists but its body was inaccessible. Corrected numerical details beyond the abstract are not verified.\nReference: Erratum: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans | 2005 | https://link.springer.com/article/10.1007/s00394-004-0524-9 | Access: Publisher identifies an erratum linked to the original paper. Correction body inaccessible; scope not independently verified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"30ca7b15-db8f-5b8b-9dfc-62b04e915585","slug":"perilla-ra-enriched-extract","display_name":"RA-enriched Perilla frutescens extract","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"a00c5b15-3afd-5b6b-b817-a3f78f6ca3cd","slug":"methyl-rosmarinic-acid","display_name":"O-Methylrosmarinic acid, site unresolved","entity_type_key":"chemical_species"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"administered constituent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract; publisher-linked erratum exists but its body was inaccessible. Corrected numerical details beyond the abstract are not verified.; Publisher identifies an erratum linked to the original paper. Correction body inaccessible; scope not independently verified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six men; placebo crossover, 10-day interval; LC-MS.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Methylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. | https://pubmed.ncbi.nlm.nih.gov/15309457/ | https://doi.org/10.1007/s00394-004-0482-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Erratum: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans | https://link.springer.com/article/10.1007/s00394-004-0524-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-human-methyl-metabolite; Methyl-RA plasma Tmax 2 h; conjugated species predominated. Erratum body not recovered.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e2f0ebe1-b3ec-53b2-8f98-4f9e99936a0c","evidence_kind":"source_excerpt","locator":"Lines 51-58","start_line":51,"end_line":58,"excerpt":"### ra-human-methyl-metabolite\n\nMethylated RA appeared in human plasma and urine after perilla extract containing 200 mg RA.\nMethyl-RA plasma Tmax 2 h; conjugated species predominated. Erratum body not recovered.\nModel and exposure: Six men; placebo crossover, 10-day interval; LC-MS.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. | 2005 | https://pubmed.ncbi.nlm.nih.gov/15309457/ | https://doi.org/10.1007/s00394-004-0482-2 | Access: Indexed primary abstract; publisher-linked erratum exists but its body was inaccessible. Corrected numerical details beyond the abstract are not verified.\nReference: Erratum: Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans | 2005 | https://link.springer.com/article/10.1007/s00394-004-0524-9 | Access: Publisher identifies an erratum linked to the original paper. Correction body inaccessible; scope not independently verified.","model_system":"Six men; placebo crossover, 10-day interval; LC-MS.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}