Component
Human circulating mangiferin exposure
Human circulating mangiferin exposure. Species, exposure and limitations are retained in each linked claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After 0.9 g orally, plasma mangiferin peaked at 38.64 +/- 6.75 ng/mL at about one hour; apparent half-life was 7.85 +/- 1.72 hours.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/26434292.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d", "start_char": 0, "end_char": 1251, "text_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d"}
- experimental_model
- Single-dose human pharmacokinetic study
- exposure
- Single oral 0.1, 0.3 or 0.9 g mangiferin
- limitations
- Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- 21 healthy Chinese men
- plain_language
- Oral intake produced measurable but low circulating parent compound.
- primary_references
- [mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. (2012). https://pubmed.ncbi.nlm.nih.gov/26434292/ DOI: 10.1016/j.foodchem.2011.10.079
- tissue_or_cell_type
- Plasma
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 236–247
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose human pharmacokinetic study · source_derived_draft · unverified_draft
### mangiferin-human-pk After 0.9 g orally, plasma mangiferin peaked at 38.64 +/- 6.75 ng/mL at about one hour; apparent half-life was 7.85 +/- 1.72 hours. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Oral intake produced measurable but low circulating parent compound. organism: 21 healthy Chinese men tissue_or_cell_type: Plasma experimental_model: Single-dose human pharmacokinetic study limitations: Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement. exposure: Single oral 0.1, 0.3 or 0.9 g mangiferin evidence_span: {"source_cache": "artifacts/mangiferin-research/26434292.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d", "start_char": 0, "end_char": 1251, "text_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d"} [mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. (2012). https://pubmed.ncbi.nlm.nih.gov/26434292/ DOI: 10.1016/j.foodchem.2011.10.079
Complete structured claim and evidenceHuman mangiferin pharmacokinetics were nonlinear across the tested doses.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/26434292.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d", "start_char": 0, "end_char": 1251, "text_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d"}
- experimental_model
- Single-dose human pharmacokinetic study
- exposure
- Single oral 0.1, 0.3 or 0.9 g mangiferin
- limitations
- Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- 21 healthy Chinese men
- plain_language
- Increasing the dose does not imply a proportional exposure increase.
- primary_references
- [mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. (2012). https://pubmed.ncbi.nlm.nih.gov/26434292/ DOI: 10.1016/j.foodchem.2011.10.079
- tissue_or_cell_type
- Plasma
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 249–260
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose human pharmacokinetic study · source_derived_draft · unverified_draft
### mangiferin-nonlinear-pk Human mangiferin pharmacokinetics were nonlinear across the tested doses. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Increasing the dose does not imply a proportional exposure increase. organism: 21 healthy Chinese men tissue_or_cell_type: Plasma experimental_model: Single-dose human pharmacokinetic study limitations: Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement. exposure: Single oral 0.1, 0.3 or 0.9 g mangiferin evidence_span: {"source_cache": "artifacts/mangiferin-research/26434292.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d", "start_char": 0, "end_char": 1251, "text_sha256": "aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d"} [mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. (2012). https://pubmed.ncbi.nlm.nih.gov/26434292/ DOI: 10.1016/j.foodchem.2011.10.079
Complete structured claim and evidenceMLES produced 2.44-fold higher AUC over 24 hours than MLE60 in the crossover comparison.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/39942566.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7f3b135e29a0a2b6268f49880822ee862a25c62b401ef8046a5feb1667b06330", "start_char": 0, "end_char": 1283, "text_sha256": "7f3b135e29a0a2b6268f49880822ee862a25c62b401ef8046a5feb1667b06330"}
- experimental_model
- Human crossover pharmacokinetic comparison
- exposure
- Two standardized 60% mango-leaf extracts; seven-day washout
- limitations
- Relative exposure comparison of formulations, not absolute bioavailability, pure-compound equivalence or demonstrated clinical benefit.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- 12 adults, six women
- plain_language
- The soluble salt preparation changed circulating exposure.
- primary_references
- [mangiferin-p39942566] Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation. (2025). https://pubmed.ncbi.nlm.nih.gov/39942566/ DOI: 10.3390/molecules30030461
- tissue_or_cell_type
- Plasma
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 262–273
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human crossover pharmacokinetic comparison · source_derived_draft · unverified_draft
### mangiferin-salt-exposure MLES produced 2.44-fold higher AUC over 24 hours than MLE60 in the crossover comparison. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The soluble salt preparation changed circulating exposure. organism: 12 adults, six women tissue_or_cell_type: Plasma experimental_model: Human crossover pharmacokinetic comparison limitations: Relative exposure comparison of formulations, not absolute bioavailability, pure-compound equivalence or demonstrated clinical benefit. exposure: Two standardized 60% mango-leaf extracts; seven-day washout evidence_span: {"source_cache": "artifacts/mangiferin-research/39942566.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7f3b135e29a0a2b6268f49880822ee862a25c62b401ef8046a5feb1667b06330", "start_char": 0, "end_char": 1283, "text_sha256": "7f3b135e29a0a2b6268f49880822ee862a25c62b401ef8046a5feb1667b06330"} [mangiferin-p39942566] Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation. (2025). https://pubmed.ncbi.nlm.nih.gov/39942566/ DOI: 10.3390/molecules30030461
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.