{"id":"b126b647-f811-5bf3-a4b2-bb64cdf553c2","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-human-pk","predicate":"has_measured_exposure","statement":"After 0.9 g orally, plasma mangiferin peaked at 38.64 +/- 6.75 ng/mL at about one hour; apparent half-life was 7.85 +/- 1.72 hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bfb3ce7d-7f42-55ae-925e-a76ee9a5c16d","mechanism_event_label":"Oral intake produced measurable but low circulating parent compound.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"88492857-be5b-59c0-9c7b-7a9419395d59","slug":"mangiferin-plasma-exposure","display_name":"Human circulating mangiferin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bfb3ce7d-7f42-55ae-925e-a76ee9a5c16d","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-human-pk-event","event_type":"observed_intervention","label":"Oral intake produced measurable but low circulating parent compound.","description":"After 0.9 g orally, plasma mangiferin peaked at 38.64 +/- 6.75 ng/mL at about one hour; apparent half-life was 7.85 +/- 1.72 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"88492857-be5b-59c0-9c7b-7a9419395d59","slug":"mangiferin-plasma-exposure","display_name":"Human circulating mangiferin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/26434292.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d\", \"start_char\": 0, \"end_char\": 1251, \"text_sha256\": \"aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-dose human pharmacokinetic study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Single oral 0.1, 0.3 or 0.9 g mangiferin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"21 healthy Chinese men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Oral intake produced measurable but low circulating parent compound.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. (2012). https://pubmed.ncbi.nlm.nih.gov/26434292/ DOI: 10.1016/j.foodchem.2011.10.079","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"92b9784e-2d7e-5656-bfdf-12dced9c0ee2","evidence_kind":"source_excerpt","locator":"Lines 236-247","start_line":236,"end_line":247,"excerpt":"### mangiferin-human-pk\nAfter 0.9 g orally, plasma mangiferin peaked at 38.64 +/- 6.75 ng/mL at about one hour; apparent half-life was 7.85 +/- 1.72 hours.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Oral intake produced measurable but low circulating parent compound.\norganism: 21 healthy Chinese men\ntissue_or_cell_type: Plasma\nexperimental_model: Single-dose human pharmacokinetic study\nlimitations: Small pharmacokinetic study; no intravenous comparator or demonstration of cellular target engagement.\nexposure: Single oral 0.1, 0.3 or 0.9 g mangiferin\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/26434292.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d\", \"start_char\": 0, \"end_char\": 1251, \"text_sha256\": \"aa87147889d9de521835562b716d5afe1c1458cd33ff3b7ff7ac67494fcfcd7d\"}\n[mangiferin-p26434292] Pharmacokinetic study of mangiferin in human plasma after oral administration. 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