Component
Mammalian GLUT3 orthologs
SLC2A3 ortholog group used only for the 1997 heterologous-expression record; donor species of each clone not verified from the accessible abstract.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Mammalian GLUT3 expressed in Xenopus oocytes transported DHA with apparent Km 1.7 ± 0.3 mM; reduced ascorbate was not transported in the screen.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression
- exposure
- Heterologous GLUT expression and DHA uptake
- limitations
- In vitro apparent kinetics; donor species unresolved, so retained as ortholog group rather than a human-specific claim.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Xenopus laevis host; mammalian clone donor not verified
- plain_language
- GLUT3 can carry oxidized vitamin C; it does not substitute directly for an ascorbate transporter.
- primary_references
- [rumsey1997] Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. (1997). https://pubmed.ncbi.nlm.nih.gov/9228080/ DOI: 10.1074/jbc.272.30.18982
- tissue_or_cell_type
- Oocyte membrane
- transport_effect
- raises DHA transport measured in expressing oocytes with an apparent Km of 1.7 mM.
- transport_pool
- the expressing cell DHA transport measured in expressing oocytes with an apparent Km of 1.7 mM.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 260–271
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression · source_derived_draft · unverified_draft
### vc-transport-glut3-dha Mammalian GLUT3 expressed in Xenopus oocytes transported DHA with apparent Km 1.7 ± 0.3 mM; reduced ascorbate was not transported in the screen. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: GLUT3 can carry oxidized vitamin C; it does not substitute directly for an ascorbate transporter. organism: Xenopus laevis host; mammalian clone donor not verified tissue_or_cell_type: Oocyte membrane experimental_model: Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression limitations: In vitro apparent kinetics; donor species unresolved, so retained as ortholog group rather than a human-specific claim. exposure: Heterologous GLUT expression and DHA uptake cross_nutrient: false [rumsey1997] Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. (1997). https://pubmed.ncbi.nlm.nih.gov/9228080/ DOI: 10.1074/jbc.272.30.18982
Complete structured claim and evidence
Where it participates (unsigned role)
D-glucose inhibited GLUT1- and GLUT3-mediated DHA uptake in the oocyte expression system.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression
- exposure
- D-glucose during heterologous-transporter DHA uptake
- limitations
- Not evidence that eating carbohydrate causes vitamin C deficiency; do not generalize across transporters, redox forms or tissue kinetics.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Xenopus laevis host; mammalian clones
- plain_language
- Glucose competed with oxidized vitamin C uptake in this laboratory transport model.
- primary_references
- [rumsey1997] Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. (1997). https://pubmed.ncbi.nlm.nih.gov/9228080/ DOI: 10.1074/jbc.272.30.18982
- tissue_or_cell_type
- Oocyte membrane
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 273–284
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression · source_derived_draft · unverified_draft
### vc-transport-glut-glucose-inhibition D-glucose inhibited GLUT1- and GLUT3-mediated DHA uptake in the oocyte expression system. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glucose competed with oxidized vitamin C uptake in this laboratory transport model. organism: Xenopus laevis host; mammalian clones tissue_or_cell_type: Oocyte membrane experimental_model: Mammalian GLUT cDNAs expressed in Xenopus laevis oocytes; CHO overexpression limitations: Not evidence that eating carbohydrate causes vitamin C deficiency; do not generalize across transporters, redox forms or tissue kinetics. exposure: D-glucose during heterologous-transporter DHA uptake cross_nutrient: true [rumsey1997] Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. (1997). https://pubmed.ncbi.nlm.nih.gov/9228080/ DOI: 10.1074/jbc.272.30.18982
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.