Component

LRAT loss

Genetic or experimental loss of LRAT protein activity; distinct from dietary vitamin A deprivation. LRAT loss is an experimental or genetic machinery state, not dietary vitamin A deficiency.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Lrat deletion severely depleted the ocular all-trans-retinyl ester pool in mice.

    LRAT loss → All-trans-retinyl esters source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Lrat knockout versus controls
    limitations
    Other tissues and dietary deficiency are separate questions.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Without LRAT, the eye cannot maintain its normal ester reserve.
    primary_references
    [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
    tissue_or_cell_type
    Eye/RPE
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 701–710

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat knockout versus controls · source_derived_draft · unverified_draft

    ### a-vision-lrat-esters Lrat deletion severely depleted the ocular all-trans-retinyl ester pool in mice. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Without LRAT, the eye cannot maintain its normal ester reserve. organism: Mus musculus tissue_or_cell_type: Eye/RPE experimental_model: Lrat knockout versus controls limitations: Other tissues and dietary deficiency are separate questions. [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
    Complete structured claim and evidence

  2. Lrat-null mice had severely attenuated rod and cone visual function by electroretinography and pupil-response testing.

    LRAT loss → Visual sensitivity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Electroretinography and pupillary constriction
    limitations
    The phenotype tests a genetic esterification defect.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    plain_language
    Loss of retinol esterification impaired measured vision.
    primary_references
    [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
    tissue_or_cell_type
    Eye
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 712–721

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Electroretinography and pupillary constriction · source_derived_draft · unverified_draft

    ### a-vision-lrat-visual-function Lrat-null mice had severely attenuated rod and cone visual function by electroretinography and pupil-response testing. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of retinol esterification impaired measured vision. organism: Mus musculus tissue_or_cell_type: Eye experimental_model: Electroretinography and pupillary constriction limitations: The phenotype tests a genetic esterification defect. [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil.

    Lecithin:retinol acyltransferase / LRAT → Chylomicron retinoid delivery source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_location
    Figure 3
    experimental_model
    Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.
    exposure
    6 micrograms retinol in peanut oil; P-407 clearance blockade; sampling at three hours.
    limitations
    Clearance was pharmacologically blocked; remaining enzyme identity was not established here.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    outcome
    Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil.
    plain_language
    Alternative esterification partly handles absorbed retinol when LRAT is missing.
    primary_references
    [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    tissue_or_cell_type
    Intestine and isolated chylomicrons
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 346–358

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. · source_derived_draft · unverified_draft

    ### va-lrat-chylomicron-retinoids Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Alternative esterification partly handles absorbed retinol when LRAT is missing. organism: Mus musculus tissue_or_cell_type: Intestine and isolated chylomicrons experimental_model: Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. limitations: Clearance was pharmacologically blocked; remaining enzyme identity was not established here. exposure: 6 micrograms retinol in peanut oil; P-407 clearance blockade; sampling at three hours. outcome: Lrat-null mice still secreted chylomicron retinyl esters whose acyl composition reflected the gavage oil. evidence_location: Figure 3 [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    Complete structured claim and evidence

  2. One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.

    Lecithin:retinol acyltransferase / LRAT → Serum retinol concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_location
    Figure 6
    experimental_model
    Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.
    exposure
    Three-month-old males and females; one month of retinoid-free diet.
    limitations
    Combined genetic and dietary perturbation; not a human depletion timetable.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    outcome
    One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.
    plain_language
    Poor storage made dietary vitamin A withdrawal affect blood retinol sooner.
    primary_references
    [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    tissue_or_cell_type
    Serum
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 360–372

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. · source_derived_draft · unverified_draft

    ### va-lrat-dietary-depletion-retinol One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type. Condition category: nutrient_deficiency nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Poor storage made dietary vitamin A withdrawal affect blood retinol sooner. organism: Mus musculus tissue_or_cell_type: Serum experimental_model: Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. limitations: Combined genetic and dietary perturbation; not a human depletion timetable. exposure: Three-month-old males and females; one month of retinoid-free diet. outcome: One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type. evidence_location: Figure 6 [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    Complete structured claim and evidence

  3. Lrat-null mice retained only trace hepatic retinyl esters.

    Lecithin:retinol acyltransferase / LRAT → Hepatic retinyl ester storage source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_location
    Abstract
    experimental_model
    Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.
    exposure
    Lrat deletion on a retinoid-sufficient control diet.
    limitations
    Adipose stores were preserved or increased; deficiency is not uniform across tissues.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    outcome
    Lrat-null mice retained only trace hepatic retinyl esters.
    plain_language
    Loss of LRAT removes most liver vitamin A storage.
    primary_references
    [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    tissue_or_cell_type
    Liver
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 332–344

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. · source_derived_draft · unverified_draft

    ### va-lrat-loss-stores Lrat-null mice retained only trace hepatic retinyl esters. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of LRAT removes most liver vitamin A storage. organism: Mus musculus tissue_or_cell_type: Liver experimental_model: Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet. limitations: Adipose stores were preserved or increased; deficiency is not uniform across tissues. exposure: Lrat deletion on a retinoid-sufficient control diet. outcome: Lrat-null mice retained only trace hepatic retinyl esters. evidence_location: Abstract [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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