{"id":"fcb9d0bc-2209-56f5-8831-25163a047446","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lrat-dietary-depletion-retinol","predicate":"buffers","statement":"One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e8314e7c-24f2-57ce-8f32-d4d685e711ea","mechanism_event_label":"Poor storage made dietary vitamin A withdrawal affect blood retinol sooner.","subject":{"id":"f7ce5851-df6d-54ed-b467-482480d26ff9","slug":"lrat","display_name":"Lecithin:retinol acyltransferase / LRAT","entity_type_key":"protein"},"object":{"id":"4f9db882-aaee-5149-820f-0cfcb9e63931","slug":"serum-retinol-concentration","display_name":"Serum retinol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e8314e7c-24f2-57ce-8f32-d4d685e711ea","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lrat-dietary-depletion-retinol-event","event_type":"biochemical_relationship","label":"Poor storage made dietary vitamin A withdrawal affect blood retinol sooner.","description":"One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"52a8dc1b-c938-547b-bf75-b2f378b2272e","slug":"lrat-loss","display_name":"LRAT loss","entity_type_key":"protein_state"},"role":"experimental-machinery-state","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f7ce5851-df6d-54ed-b467-482480d26ff9","slug":"lrat","display_name":"Lecithin:retinol acyltransferase / LRAT","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4f9db882-aaee-5149-820f-0cfcb9e63931","slug":"serum-retinol-concentration","display_name":"Serum retinol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"5a3a88c5-9485-550f-91a4-18f868d42996","evidence_kind":"source_excerpt","locator":"Lines 360-372","start_line":360,"end_line":372,"excerpt":"### va-lrat-dietary-depletion-retinol\nOne month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Poor storage made dietary vitamin A withdrawal affect blood retinol sooner.\norganism: Mus musculus\ntissue_or_cell_type: Serum\nexperimental_model: Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.\nlimitations: Combined genetic and dietary perturbation; not a human depletion timetable.\nexposure: Three-month-old males and females; one month of retinoid-free diet.\noutcome: One month of dietary retinoid withdrawal lowered serum retinol in Lrat-null mice, with no comparable fall in wild type.\nevidence_location: Figure 6\n[va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200","model_system":"Lrat-knockout mice; retinol gavage and one-month retinoid-deficient diet.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-obyrne-2005] Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT) (2005). https://pmc.ncbi.nlm.nih.gov/articles/PMC1352312/ DOI: 10.1074/jbc.M507924200","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}