Component
All-trans-retinyl esters
Ester class with an all-trans-retinyl moiety; individual acyl species are not resolved here.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lrat deletion severely depleted the ocular all-trans-retinyl ester pool in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Lrat knockout versus controls
- limitations
- Other tissues and dietary deficiency are separate questions.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Without LRAT, the eye cannot maintain its normal ester reserve.
- primary_references
- [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
- tissue_or_cell_type
- Eye/RPE
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 701–710
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lrat knockout versus controls · source_derived_draft · unverified_draft
### a-vision-lrat-esters Lrat deletion severely depleted the ocular all-trans-retinyl ester pool in mice. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Without LRAT, the eye cannot maintain its normal ester reserve. organism: Mus musculus tissue_or_cell_type: Eye/RPE experimental_model: Lrat knockout versus controls limitations: Other tissues and dietary deficiency are separate questions. [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
Complete structured claim and evidence
Where it participates (unsigned role)
Lrat-null mice had severely attenuated rod and cone visual function by electroretinography and pupil-response testing.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Electroretinography and pupillary constriction
- limitations
- The phenotype tests a genetic esterification defect.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Loss of retinol esterification impaired measured vision.
- primary_references
- [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
- tissue_or_cell_type
- Eye
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 712–721
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Electroretinography and pupillary constriction · source_derived_draft · unverified_draft
### a-vision-lrat-visual-function Lrat-null mice had severely attenuated rod and cone visual function by electroretinography and pupil-response testing. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of retinol esterification impaired measured vision. organism: Mus musculus tissue_or_cell_type: Eye experimental_model: Electroretinography and pupillary constriction limitations: The phenotype tests a genetic esterification defect. [batten-2004] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004). https://pubmed.ncbi.nlm.nih.gov/14684738/ DOI: 10.1074/jbc.M312410200
Complete structured claim and evidenceRecombinant RPE65 catalyzed conversion of all-trans-retinyl esters to 11-cis-retinol in visual-cycle reconstitution.
Experimental context and source evidence
- experimental_model
- Recombinant enzyme reconstitution
- limitations
- Production of the aldehyde requires a subsequent oxidation step.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- QBI-293A human cells and COS-1 monkey cells
- plain_language
- RPE65 converts the ester pool into the cis alcohol needed for chromophore renewal.
- primary_references
- [moiseyev-2005] RPE65 is the isomerohydrolase in the retinoid visual cycle (2005). https://pubmed.ncbi.nlm.nih.gov/16116091/ DOI: 10.1073/pnas.0503460102
- tissue_or_cell_type
- RPE visual-cycle biochemical model
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 666–675
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant enzyme reconstitution · source_derived_draft · unverified_draft
### a-vision-rpe65-isomerization Recombinant RPE65 catalyzed conversion of all-trans-retinyl esters to 11-cis-retinol in visual-cycle reconstitution. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: RPE65 converts the ester pool into the cis alcohol needed for chromophore renewal. organism: QBI-293A human cells and COS-1 monkey cells tissue_or_cell_type: RPE visual-cycle biochemical model experimental_model: Recombinant enzyme reconstitution limitations: Production of the aldehyde requires a subsequent oxidation step. [moiseyev-2005] RPE65 is the isomerohydrolase in the retinoid visual cycle (2005). https://pubmed.ncbi.nlm.nih.gov/16116091/ DOI: 10.1073/pnas.0503460102
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.