Component

LDL vitamin E consumption during oxidation

LDL vitamin E consumption during oxidation. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Lipoic acid blunted copper-driven LDL oxidation and associated vitamin E consumption in the endothelial-cell experiment.

    Lipoic acid → LDL vitamin E consumption during oxidation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ala-research/18026819.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a", "start_char": 0, "end_char": 1329, "text_sha256": "a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a"}
    experimental_model
    Human endothelial-cell and extracellular LDL oxidation experiments
    exposure
    40–80 micromolar lipoic acid; menadione or copper/LDL challenge
    limitations
    Compartment and oxidant matter; intracellular vitamin C and LDL vitamin E are distinct readouts.
    nutrient_topic
    Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
    organism
    Human cell line and human LDL
    plain_language
    The extracellular lipoprotein compartment showed less oxidative damage.
    primary_references
    [ala-p18026819] alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18026819/ DOI: 10.1007/s11010-007-9650-z
    tissue_or_cell_type
    EA.hy926 endothelial cells; extracellular LDL

    Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 1014–1025

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human endothelial-cell and extracellular LDL oxidation experiments · source_derived_draft · unverified_draft

    ### ala-ldl-vitamin-e-sparing Lipoic acid blunted copper-driven LDL oxidation and associated vitamin E consumption in the endothelial-cell experiment. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The extracellular lipoprotein compartment showed less oxidative damage. organism: Human cell line and human LDL tissue_or_cell_type: EA.hy926 endothelial cells; extracellular LDL experimental_model: Human endothelial-cell and extracellular LDL oxidation experiments limitations: Compartment and oxidant matter; intracellular vitamin C and LDL vitamin E are distinct readouts. exposure: 40–80 micromolar lipoic acid; menadione or copper/LDL challenge evidence_span: {"source_cache": "artifacts/ala-research/18026819.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a", "start_char": 0, "end_char": 1329, "text_sha256": "a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a"} [ala-p18026819] alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18026819/ DOI: 10.1007/s11010-007-9650-z
    Complete structured claim and evidence

  2. Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.

    Betanin → LDL vitamin E consumption during oxidation source_derived_draftungraded
    Experimental context and source evidence
    dose
    25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation
    duration
    Kinetic oxidation assay; incubation duration not specified in accessed abstract
    evidence_access
    Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.
    evidence_scope
    literature_reviewed; source-derived curation, not universally established human effects
    experimental_model
    Human pooled plasma from 10 healthy donors; isolated LDL
    limitations
    Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay.
    nutrient_topic
    Betalains collection; each molecular form, species, exposure and preparation remains explicit. · Betalains
    organism
    Human pooled plasma from 10 healthy donors; isolated LDL
    plain_language
    Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.
    primary_references
    Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490
    route
    Ex vivo spiking, not oral dosing
    tissue
    Plasma and LDL

    Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 97–105

    Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Human pooled plasma from 10 healthy donors; isolated LDL · source_derived_draft · unverified_draft

    ## betalains-betanin-vitamin-e-null Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment. Model/species: Human pooled plasma from 10 healthy donors; isolated LDL Tissue: Plasma and LDL Exposure: 25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation Route: Ex vivo spiking, not oral dosing Duration: Kinetic oxidation assay; incubation duration not specified in accessed abstract Limits: Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay. Primary reference: Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490
    Complete structured claim and evidence

  3. Indicaxanthin preserved LDL vitamin E early during oxidation; combined action protected LDL more than sequential separate action.

    Indicaxanthin → LDL vitamin E consumption during oxidation source_derived_draftungraded
    Experimental context and source evidence
    dose
    25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation
    duration
    Kinetic oxidation assay; incubation duration not specified in accessed abstract
    evidence_access
    Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.
    evidence_scope
    literature_reviewed; source-derived curation, not universally established human effects
    experimental_model
    Human pooled plasma from 10 healthy donors; isolated LDL
    limitations
    Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay. The authors infer assay synergy; direct tocopheroxyl-radical recycling is not established.
    nutrient_topic
    Betalains collection; each molecular form, species, exposure and preparation remains explicit. · Betalains
    organism
    Human pooled plasma from 10 healthy donors; isolated LDL
    plain_language
    Indicaxanthin preserved LDL vitamin E early during oxidation; combined action protected LDL more than sequential separate action.
    primary_references
    Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490
    route
    Ex vivo spiking, not oral dosing
    tissue
    Plasma and LDL

    Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 87–95

    Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Human pooled plasma from 10 healthy donors; isolated LDL · source_derived_draft · unverified_draft

    ## betalains-indicaxanthin-vitamin-e Indicaxanthin preserved LDL vitamin E early during oxidation; combined action protected LDL more than sequential separate action. Model/species: Human pooled plasma from 10 healthy donors; isolated LDL Tissue: Plasma and LDL Exposure: 25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation Route: Ex vivo spiking, not oral dosing Duration: Kinetic oxidation assay; incubation duration not specified in accessed abstract Limits: Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay. The authors infer assay synergy; direct tocopheroxyl-radical recycling is not established. Primary reference: Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards