{"id":"4955885a-fad6-5d32-a0da-2658e2fc6e6a","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-betanin-vitamin-e-null","predicate":"does_not_delay","statement":"Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"7597a5d4-5b76-54cc-94f0-b4084b11119b","mechanism_event_label":"Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.","subject":{"id":"6c12bb61-c9c2-5c6d-a087-a292145ccaf0","slug":"betanin","display_name":"Betanin","entity_type_key":"small_molecule"},"object":{"id":"bfac2114-84d0-5e0e-a8c5-bcf54b6f8c94","slug":"ldl-vitamin-e-consumption","display_name":"LDL vitamin E consumption during oxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7597a5d4-5b76-54cc-94f0-b4084b11119b","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-betanin-vitamin-e-null-event","event_type":"observed_relationship","label":"Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.","description":"Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6c12bb61-c9c2-5c6d-a087-a292145ccaf0","slug":"betanin","display_name":"Betanin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bfac2114-84d0-5e0e-a8c5-bcf54b6f8c94","slug":"ldl-vitamin-e-consumption","display_name":"LDL vitamin E consumption during oxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"19901d14-1463-5a22-b2f5-afdfb70a7a23","slug":"ldl-particles","display_name":"Low-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Kinetic oxidation assay; incubation duration not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human pooled plasma from 10 healthy donors; isolated LDL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Betalains collection; each molecular form, species, exposure and preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"betalains","display_name":"Betalains","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human pooled plasma from 10 healthy donors; isolated LDL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Betanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo spiking, not oral dosing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma and LDL","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b040ac8b-05e7-533b-93f4-ea4b97a41cde","evidence_kind":"source_excerpt","locator":"Lines 97-105","start_line":97,"end_line":105,"excerpt":"## betalains-betanin-vitamin-e-null\nBetanin did not produce the early vitamin E preservation observed with indicaxanthin in this LDL experiment.\nModel/species: Human pooled plasma from 10 healthy donors; isolated LDL\nTissue: Plasma and LDL\nExposure: 25-100 micromolar pigment added to plasma; copper-triggered LDL oxidation\nRoute: Ex vivo spiking, not oral dosing\nDuration: Kinetic oxidation assay; incubation duration not specified in accessed abstract\nLimits: Plasma spiking exceeds typical dietary parent-pigment exposure; vitamin synergy refers only to this assay.\nPrimary reference: Increased resistance to oxidation of betalain-enriched human low density lipoproteins. (2003). https://pubmed.ncbi.nlm.nih.gov/12868496/ DOI: 10.1080/1071576031000097490","model_system":"Human pooled plasma from 10 healthy donors; isolated LDL","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; an original paraphrase with an individually identified primary reference.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"be94d093-444c-5729-8831-bc33b0ef2fd7","stable_key":"import-cab605fe-8a82-5191-9966-d19a9628c24c","title":"Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. 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