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(2008). https://pubmed.ncbi.nlm.nih.gov/18026819/ DOI: 10.1007/s11010-007-9650-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"EA.hy926 endothelial cells; extracellular LDL","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9439d66-63c9-53a3-bc18-57bd055d6028","evidence_kind":"source_excerpt","locator":"Lines 1014-1025","start_line":1014,"end_line":1025,"excerpt":"### ala-ldl-vitamin-e-sparing\nLipoic acid blunted copper-driven LDL oxidation and associated vitamin E consumption in the endothelial-cell experiment.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The extracellular lipoprotein compartment showed less oxidative damage.\norganism: Human cell line and human LDL\ntissue_or_cell_type: EA.hy926 endothelial cells; extracellular LDL\nexperimental_model: Human endothelial-cell and extracellular LDL oxidation experiments\nlimitations: Compartment and oxidant matter; intracellular vitamin C and LDL vitamin E are distinct readouts.\nexposure: 40–80 micromolar lipoic acid; menadione or copper/LDL challenge\nevidence_span: {\"source_cache\": \"artifacts/ala-research/18026819.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a\", \"start_char\": 0, \"end_char\": 1329, \"text_sha256\": \"a4dff4887489013858d07ce07ba538c62702962afa1588ae7cc83e308648e53a\"}\n[ala-p18026819] alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18026819/ DOI: 10.1007/s11010-007-9650-z","model_system":"Human endothelial-cell and extracellular LDL oxidation experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ala-p18026819] alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18026819/ DOI: 10.1007/s11010-007-9650-z","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d8afa8c2-ced9-5b28-90ca-2ac120ec7202","stable_key":"import-5d8e27d8-6a74-5560-827f-3f90908bbc34","title":"Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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