Component

Intestinal folate uptake across the brush border

Intestinal folate uptake across the brush border. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Ethanol reduces intestinal and renal uptake of folate by altering the binding and transport kinetics of folate transport systems and by reducing the expression of folate transporters, with ethanol ingestion described as the major contributor to folate deficiency.

    Ethanol → Intestinal folate uptake across the brush border source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/alcohol-research/19292860.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30", "start_char": 0, "end_char": 2909, "text_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30"}
    experimental_model
    Review of folate transport systems in relation to alcoholism-induced malabsorption
    exposure
    Chronic ethanol ingestion against folate transport
    limitations
    A review, labelled as such, used for the enumeration of routes. The individual transport measurements are recorded from their own primary papers where available.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Human and animal
    plain_language
    Alcohol attacks the vitamin at the doorway, in both gut and kidney.
    primary_references
    [alcohol-p19292860] New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. (2009). https://pubmed.ncbi.nlm.nih.gov/19292860/ DOI: 10.1111/j.1742-4658.2009.06959.x
    tissue_or_cell_type
    Intestine, liver and kidney
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 683–694

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Review of folate transport systems in relation to alcoholism-induced malabsorption · source_derived_draft · unverified_draft

    ### alcohol-ethanol-folate-transport Ethanol reduces intestinal and renal uptake of folate by altering the binding and transport kinetics of folate transport systems and by reducing the expression of folate transporters, with ethanol ingestion described as the major contributor to folate deficiency. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Alcohol attacks the vitamin at the doorway, in both gut and kidney. organism: Human and animal tissue_or_cell_type: Intestine, liver and kidney experimental_model: Review of folate transport systems in relation to alcoholism-induced malabsorption limitations: A review, labelled as such, used for the enumeration of routes. The individual transport measurements are recorded from their own primary papers where available. exposure: Chronic ethanol ingestion against folate transport evidence_span: {"source_cache": "artifacts/alcohol-research/19292860.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30", "start_char": 0, "end_char": 2909, "text_sha256": "596af06cee715270d990c6fd6f421a3cf4efe2448193da3e58a35d74c2949e30"} [alcohol-p19292860] New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. (2009). https://pubmed.ncbi.nlm.nih.gov/19292860/ DOI: 10.1111/j.1742-4658.2009.06959.x
    Complete structured claim and evidence

  2. In vivo intestinal perfusion studies in alcoholic pigs showed reduced folate absorption.

    Habitual alcohol consumption → Intestinal folate uptake across the brush border source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/alcohol-research/2596432.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13", "start_char": 0, "end_char": 1018, "text_sha256": "44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13"}
    experimental_model
    In vivo intestinal perfusion in alcoholic pigs
    exposure
    Chronic alcohol feeding with in vivo perfusion
    limitations
    A whole-animal perfusion measurement rather than a membrane preparation, in a species with human-like intestinal physiology.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Pig
    plain_language
    Measured in a living gut, the absorption really is lower.
    primary_references
    [alcohol-p2596432] Folate absorption in alcoholic pigs: in vivo intestinal perfusion studies. (1989). https://pubmed.ncbi.nlm.nih.gov/2596432/ DOI: 10.1093/ajcn/50.6.1429
    tissue_or_cell_type
    Small intestine
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 709–720

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · In vivo intestinal perfusion in alcoholic pigs · source_derived_draft · unverified_draft

    ### alcohol-pig-folate-absorption In vivo intestinal perfusion studies in alcoholic pigs showed reduced folate absorption. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Measured in a living gut, the absorption really is lower. organism: Pig tissue_or_cell_type: Small intestine experimental_model: In vivo intestinal perfusion in alcoholic pigs limitations: A whole-animal perfusion measurement rather than a membrane preparation, in a species with human-like intestinal physiology. exposure: Chronic alcohol feeding with in vivo perfusion evidence_span: {"source_cache": "artifacts/alcohol-research/2596432.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13", "start_char": 0, "end_char": 1018, "text_sha256": "44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13"} [alcohol-p2596432] Folate absorption in alcoholic pigs: in vivo intestinal perfusion studies. (1989). https://pubmed.ncbi.nlm.nih.gov/2596432/ DOI: 10.1093/ajcn/50.6.1429
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism.

    Ethanol → Reduced folate carrier expression at the intestinal brush border source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/alcohol-research/18005257.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b", "start_char": 0, "end_char": 2252, "text_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b"}
    experimental_model
    Experimental alcoholism model with intestinal brush border membrane transport measurement
    exposure
    Chronic ethanol feeding with reduced folate carrier measurement
    limitations
    Assigns the malabsorption to a named carrier. It is an animal model of chronic alcoholism.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Rat
    plain_language
    The specific carrier is made in smaller amounts.
    primary_references
    [alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. (2007). https://pubmed.ncbi.nlm.nih.gov/18005257/ DOI: 10.1111/j.1742-4658.2007.06150.x
    tissue_or_cell_type
    Intestinal brush border
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 696–707

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Experimental alcoholism model with intestinal brush border membrane transport measurement · source_derived_draft · unverified_draft

    ### alcohol-rfc-downregulation Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The specific carrier is made in smaller amounts. organism: Rat tissue_or_cell_type: Intestinal brush border experimental_model: Experimental alcoholism model with intestinal brush border membrane transport measurement limitations: Assigns the malabsorption to a named carrier. It is an animal model of chronic alcoholism. exposure: Chronic ethanol feeding with reduced folate carrier measurement evidence_span: {"source_cache": "artifacts/alcohol-research/18005257.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b", "start_char": 0, "end_char": 2252, "text_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b"} [alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. (2007). https://pubmed.ncbi.nlm.nih.gov/18005257/ DOI: 10.1111/j.1742-4658.2007.06150.x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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