{"id":"72968538-99bb-58aa-947e-930ac6a30a6c","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-pig-folate-absorption","predicate":"reduces","statement":"In vivo intestinal perfusion studies in alcoholic pigs showed reduced folate absorption.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4020d924-49ff-58ff-8b10-d37cd942fd4a","mechanism_event_label":"Measured in a living gut, the absorption really is lower.","subject":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"object":{"id":"dbcf6749-dc83-584f-8f20-1abf58247387","slug":"intestinal-folate-transport","display_name":"Intestinal folate uptake across the brush border","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4020d924-49ff-58ff-8b10-d37cd942fd4a","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-pig-folate-absorption-event","event_type":"biochemical_relationship","label":"Measured in a living gut, the absorption really is lower.","description":"In vivo intestinal perfusion studies in alcoholic pigs showed reduced folate absorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dbcf6749-dc83-584f-8f20-1abf58247387","slug":"intestinal-folate-transport","display_name":"Intestinal folate uptake across the brush border","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/2596432.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13\", \"start_char\": 0, \"end_char\": 1018, \"text_sha256\": \"44f9e82990ef618c97924f29862366c0c718c3465edd42ceb1dc89e6bcda4e13\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In vivo intestinal perfusion in alcoholic pigs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic alcohol feeding with in vivo perfusion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A whole-animal perfusion measurement rather than a membrane preparation, in a species with human-like intestinal physiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Pig","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Measured in a living gut, the absorption really is lower.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p2596432] Folate absorption in alcoholic pigs: in vivo intestinal perfusion studies. 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