{"id":"23652101-e33d-53c0-a613-de7314c5aaa3","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-rfc-downregulation","predicate":"reduces","statement":"Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"bff174f6-8654-58d3-9842-1a8735e9dff4","mechanism_event_label":"The specific carrier is made in smaller amounts.","subject":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"object":{"id":"efe03cc8-05ca-5c70-b14c-76280a4ec001","slug":"slc19a1-expression","display_name":"Reduced folate carrier expression at the intestinal brush border","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bff174f6-8654-58d3-9842-1a8735e9dff4","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-rfc-downregulation-event","event_type":"biochemical_relationship","label":"The specific carrier is made in smaller amounts.","description":"Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dbcf6749-dc83-584f-8f20-1abf58247387","slug":"intestinal-folate-transport","display_name":"Intestinal folate uptake across the brush border","entity_type_key":"cellular_process"},"role":"affected_process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"efe03cc8-05ca-5c70-b14c-76280a4ec001","slug":"slc19a1-expression","display_name":"Reduced folate carrier expression at the intestinal brush border","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/18005257.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b\", \"start_char\": 0, \"end_char\": 2252, \"text_sha256\": \"1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Experimental alcoholism model with intestinal brush border membrane transport measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic ethanol feeding with reduced folate carrier measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assigns the malabsorption to a named carrier. It is an animal model of chronic alcoholism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The specific carrier is made in smaller amounts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. 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It is an animal model of chronic alcoholism.\nexposure: Chronic ethanol feeding with reduced folate carrier measurement\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/18005257.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b\", \"start_char\": 0, \"end_char\": 2252, \"text_sha256\": \"1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b\"}\n[alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. 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