Component
Reduced folate carrier expression at the intestinal brush border
Reduced folate carrier expression at the intestinal brush border. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/18005257.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b", "start_char": 0, "end_char": 2252, "text_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b"}
- experimental_model
- Experimental alcoholism model with intestinal brush border membrane transport measurement
- exposure
- Chronic ethanol feeding with reduced folate carrier measurement
- limitations
- Assigns the malabsorption to a named carrier. It is an animal model of chronic alcoholism.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Rat
- plain_language
- The specific carrier is made in smaller amounts.
- primary_references
- [alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. (2007). https://pubmed.ncbi.nlm.nih.gov/18005257/ DOI: 10.1111/j.1742-4658.2007.06150.x
- tissue_or_cell_type
- Intestinal brush border
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 696–707
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Experimental alcoholism model with intestinal brush border membrane transport measurement · source_derived_draft · unverified_draft
### alcohol-rfc-downregulation Down-regulation of the reduced folate carrier may result in folate malabsorption across the intestinal brush border membrane during experimental alcoholism. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The specific carrier is made in smaller amounts. organism: Rat tissue_or_cell_type: Intestinal brush border experimental_model: Experimental alcoholism model with intestinal brush border membrane transport measurement limitations: Assigns the malabsorption to a named carrier. It is an animal model of chronic alcoholism. exposure: Chronic ethanol feeding with reduced folate carrier measurement evidence_span: {"source_cache": "artifacts/alcohol-research/18005257.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b", "start_char": 0, "end_char": 2252, "text_sha256": "1987e526f06b05a8f98b20048b73a9d01941fae9f69a718cc2fe134992b4a25b"} [alcohol-p18005257] Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. (2007). https://pubmed.ncbi.nlm.nih.gov/18005257/ DOI: 10.1111/j.1742-4658.2007.06150.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.