Component

Intestinal chromium uptake

Intestinal chromium uptake. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Estimated fractional chromium absorption fell from about 2% at 10 µg/day intake to about 0.5% at 40 µg/day in the study.

    Chromium → Intestinal chromium uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/4003325.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013", "start_char": 0, "end_char": 1004, "text_sha256": "e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013"}
    experimental_model
    Duplicate-diet collection and absorption estimates in 32 adults
    exposure
    Seven-day self-selected diets in 10 men and 22 women; approximate intake range 10–40 µg/day for reported absorption relation
    limitations
    Historical analytical and intake-reference context. A diet below the old suggested intake is not a validated diagnosis of chromium deficiency.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Human
    plain_language
    A greater intake did not translate into a proportionally greater absorbed fraction.
    primary_references
    [chromium-p4003325] Chromium intake, absorption and excretion of subjects consuming self-selected diets. (1985). https://pubmed.ncbi.nlm.nih.gov/4003325/ DOI: 10.1093/ajcn/41.6.1177
    tissue_or_cell_type
    Diet and whole-body absorption estimates

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 107–118

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Duplicate-diet collection and absorption estimates in 32 adults · source_derived_draft · unverified_draft

    ### chromium-human-fractional-absorption Estimated fractional chromium absorption fell from about 2% at 10 µg/day intake to about 0.5% at 40 µg/day in the study. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A greater intake did not translate into a proportionally greater absorbed fraction. organism: Human tissue_or_cell_type: Diet and whole-body absorption estimates experimental_model: Duplicate-diet collection and absorption estimates in 32 adults limitations: Historical analytical and intake-reference context. A diet below the old suggested intake is not a validated diagnosis of chromium deficiency. exposure: Seven-day self-selected diets in 10 men and 22 women; approximate intake range 10–40 µg/day for reported absorption relation evidence_span: {"source_cache": "artifacts/chromium-research/4003325.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013", "start_char": 0, "end_char": 1004, "text_sha256": "e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013"} [chromium-p4003325] Chromium intake, absorption and excretion of subjects consuming self-selected diets. (1985). https://pubmed.ncbi.nlm.nih.gov/4003325/ DOI: 10.1093/ajcn/41.6.1177
    Complete structured claim and evidence

  2. Cr(III) uptake and vascular transfer were nonsaturable across 0.2–20 µmol/L in the perfused rat intestine; the authors interpreted the behavior as passive diffusion.

    Trivalent chromium / Cr(III) → Intestinal chromium uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/2778539.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e", "start_char": 0, "end_char": 1379, "text_sha256": "1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e"}
    experimental_model
    Vascularly perfused small-intestine preparation
    exposure
    Inorganic Cr(III) 0.2–20 µmol/L; chromium-adequate diet before preparation
    limitations
    Nonsaturability supports passive uptake under this preparation; it does not identify a human transporter or cover all supplement complexes.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Rat
    plain_language
    This rat preparation did not show a saturable uptake system over the tested range.
    primary_references
    [chromium-p2778539] Absorption of inorganic, trivalent chromium from the vascularly perfused rat small intestine. (1989). https://pubmed.ncbi.nlm.nih.gov/2778539/ DOI: 10.1093/jn/119.8.1138
    tissue_or_cell_type
    Intestinal lumen, wall and vascular perfusate

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 94–105

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Vascularly perfused small-intestine preparation · source_derived_draft · unverified_draft

    ### chromium-rat-intestinal-uptake Cr(III) uptake and vascular transfer were nonsaturable across 0.2–20 µmol/L in the perfused rat intestine; the authors interpreted the behavior as passive diffusion. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: This rat preparation did not show a saturable uptake system over the tested range. organism: Rat tissue_or_cell_type: Intestinal lumen, wall and vascular perfusate experimental_model: Vascularly perfused small-intestine preparation limitations: Nonsaturability supports passive uptake under this preparation; it does not identify a human transporter or cover all supplement complexes. exposure: Inorganic Cr(III) 0.2–20 µmol/L; chromium-adequate diet before preparation evidence_span: {"source_cache": "artifacts/chromium-research/2778539.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e", "start_char": 0, "end_char": 1379, "text_sha256": "1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e"} [chromium-p2778539] Absorption of inorganic, trivalent chromium from the vascularly perfused rat small intestine. (1989). https://pubmed.ncbi.nlm.nih.gov/2778539/ DOI: 10.1093/jn/119.8.1138
    Complete structured claim and evidence

  3. Apparent absorption in the human comparison was about 0.8–1%, higher than the 0.04–0.24% range across the tested rat complexes.

    Chromium(III) picolinate / CrPic → Intestinal chromium uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/22814636.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "392f4199c0cee925fff5f02ee9ce7d12047f9be5d278a55d09da0a3bb707c4b6", "start_char": 0, "end_char": 1673, "text_sha256": "392f4199c0cee925fff5f02ee9ce7d12047f9be5d278a55d09da0a3bb707c4b6"}
    experimental_model
    Radiolabeled-compound whole-body counting in rats and a human volunteer
    exposure
    Oral 51Cr-labeled supplement complexes; human intraindividual comparison of picolinate and phenylalaninate
    limitations
    Human component was a volunteer comparison, not a large population trial. Apparent absorption, absorbed amount before early urinary loss and seven-day retention are different quantities.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Rat and human; species-specific results retained
    plain_language
    Absorption differed between humans and rats; the rat percentage should not be assigned directly to people.
    primary_references
    [chromium-p22814636] Bioavailability of chromium(III)-supplements in rats and humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22814636/ DOI: 10.1007/s10534-012-9571-5
    tissue_or_cell_type
    Intestinal uptake, urine and whole-body retention

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 133–144

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiolabeled-compound whole-body counting in rats and a human volunteer · source_derived_draft · unverified_draft

    ### chromium-species-bioavailability Apparent absorption in the human comparison was about 0.8–1%, higher than the 0.04–0.24% range across the tested rat complexes. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Absorption differed between humans and rats; the rat percentage should not be assigned directly to people. organism: Rat and human; species-specific results retained tissue_or_cell_type: Intestinal uptake, urine and whole-body retention experimental_model: Radiolabeled-compound whole-body counting in rats and a human volunteer limitations: Human component was a volunteer comparison, not a large population trial. Apparent absorption, absorbed amount before early urinary loss and seven-day retention are different quantities. exposure: Oral 51Cr-labeled supplement complexes; human intraindividual comparison of picolinate and phenylalaninate evidence_span: {"source_cache": "artifacts/chromium-research/22814636.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "392f4199c0cee925fff5f02ee9ce7d12047f9be5d278a55d09da0a3bb707c4b6", "start_char": 0, "end_char": 1673, "text_sha256": "392f4199c0cee925fff5f02ee9ce7d12047f9be5d278a55d09da0a3bb707c4b6"} [chromium-p22814636] Bioavailability of chromium(III)-supplements in rats and humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22814636/ DOI: 10.1007/s10534-012-9571-5
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards