{"id":"a364b619-366c-5685-84e1-3a05de1fbc6e","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-rat-intestinal-uptake","predicate":"undergoes","statement":"Cr(III) uptake and vascular transfer were nonsaturable across 0.2–20 µmol/L in the perfused rat intestine; the authors interpreted the behavior as passive diffusion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4619ce31-c201-55a1-bdb8-f4493d996abf","mechanism_event_label":"This rat preparation did not show a saturable uptake system over the tested range.","subject":{"id":"2d160bdf-c463-5f93-9e50-137f41a1f369","slug":"chromium-iii","display_name":"Trivalent chromium / Cr(III)","entity_type_key":"ion"},"object":{"id":"ac8abeb4-1398-58cc-91ca-f16e97415f15","slug":"intestinal-chromium-uptake","display_name":"Intestinal chromium uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4619ce31-c201-55a1-bdb8-f4493d996abf","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-rat-intestinal-uptake-event","event_type":"biochemical_relationship","label":"This rat preparation did not show a saturable uptake system over the tested range.","description":"Cr(III) uptake and vascular transfer were nonsaturable across 0.2–20 µmol/L in the perfused rat intestine; the authors interpreted the behavior as passive diffusion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d160bdf-c463-5f93-9e50-137f41a1f369","slug":"chromium-iii","display_name":"Trivalent chromium / Cr(III)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac8abeb4-1398-58cc-91ca-f16e97415f15","slug":"intestinal-chromium-uptake","display_name":"Intestinal chromium uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/2778539.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e\", \"start_char\": 0, \"end_char\": 1379, \"text_sha256\": \"1c3f4249245a1ed57e89179e1f751a537e52fe566de25a9859833895553d2e0e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Vascularly perfused small-intestine preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Inorganic Cr(III) 0.2–20 µmol/L; chromium-adequate diet before preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonsaturability supports passive uptake under this preparation; it does not identify a human transporter or cover all supplement complexes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This rat preparation did not show a saturable uptake system over the tested range.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p2778539] Absorption of inorganic, trivalent chromium from the vascularly perfused rat small intestine. 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