{"id":"e10eadfc-aff6-5b61-9eec-830b75679e96","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-human-fractional-absorption","predicate":"intake_modulates","statement":"Estimated fractional chromium absorption fell from about 2% at 10 µg/day intake to about 0.5% at 40 µg/day in the study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2bb7f3cb-72b3-5c8e-9840-e5ee876397b9","mechanism_event_label":"A greater intake did not translate into a proportionally greater absorbed fraction.","subject":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"object":{"id":"ac8abeb4-1398-58cc-91ca-f16e97415f15","slug":"intestinal-chromium-uptake","display_name":"Intestinal chromium uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2bb7f3cb-72b3-5c8e-9840-e5ee876397b9","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-human-fractional-absorption-event","event_type":"observed_intervention","label":"A greater intake did not translate into a proportionally greater absorbed fraction.","description":"Estimated fractional chromium absorption fell from about 2% at 10 µg/day intake to about 0.5% at 40 µg/day in the study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac8abeb4-1398-58cc-91ca-f16e97415f15","slug":"intestinal-chromium-uptake","display_name":"Intestinal chromium uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/4003325.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013\", \"start_char\": 0, \"end_char\": 1004, \"text_sha256\": \"e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Duplicate-diet collection and absorption estimates in 32 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Seven-day self-selected diets in 10 men and 22 women; approximate intake range 10–40 µg/day for reported absorption relation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical analytical and intake-reference context. A diet below the old suggested intake is not a validated diagnosis of chromium deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A greater intake did not translate into a proportionally greater absorbed fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p4003325] Chromium intake, absorption and excretion of subjects consuming self-selected diets. (1985). https://pubmed.ncbi.nlm.nih.gov/4003325/ DOI: 10.1093/ajcn/41.6.1177","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Diet and whole-body absorption estimates","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3a63819-c200-5b51-8adf-41647ef64dbd","evidence_kind":"source_excerpt","locator":"Lines 107-118","start_line":107,"end_line":118,"excerpt":"### chromium-human-fractional-absorption\nEstimated fractional chromium absorption fell from about 2% at 10 µg/day intake to about 0.5% at 40 µg/day in the study.\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A greater intake did not translate into a proportionally greater absorbed fraction.\norganism: Human\ntissue_or_cell_type: Diet and whole-body absorption estimates\nexperimental_model: Duplicate-diet collection and absorption estimates in 32 adults\nlimitations: Historical analytical and intake-reference context. A diet below the old suggested intake is not a validated diagnosis of chromium deficiency.\nexposure: Seven-day self-selected diets in 10 men and 22 women; approximate intake range 10–40 µg/day for reported absorption relation\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/4003325.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013\", \"start_char\": 0, \"end_char\": 1004, \"text_sha256\": \"e60f6f96d0d74aaba16b4f3e04bdd6c9fe3944c6605df6c4e84180d1987e2013\"}\n[chromium-p4003325] Chromium intake, absorption and excretion of subjects consuming self-selected diets. 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