Component

Intestinal beta-carotene absorption

Absorption endpoint; distinct from cleavage efficiency.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The beta-carotene serum AUC did not differ when beta-carotene was taken alone or with lycopene.

    Lycopene → Intestinal beta-carotene absorption source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/9278568.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e318f6fef0bfed88403fa2adf46f9713ebddfe6ea586c29614e820442c57d056", "start_char": 0, "end_char": 1510, "text_sha256": "e318f6fef0bfed88403fa2adf46f9713ebddfe6ea586c29614e820442c57d056"}
    experimental_model
    Randomized-order double-blind crossover dosing experiment
    exposure
    60 mg beta-carotene, 60 mg lycopene, or 60 mg of each together
    limitations
    Acute high-dose study; does not justify routine co-supplementation or establish universal competition rules.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human, ten healthy men
    plain_language
    The measured interaction was not symmetrical.
    primary_references
    [lycopene-p9278568] Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. (1997). https://pubmed.ncbi.nlm.nih.gov/9278568/ DOI: 10.1093/jn/127.9.1833
    tissue_or_cell_type
    Serum carotenoid AUC over 24 hours

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 793–804

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order double-blind crossover dosing experiment · source_derived_draft · unverified_draft

    ### lycopene-beta-carotene-response-null The beta-carotene serum AUC did not differ when beta-carotene was taken alone or with lycopene. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured interaction was not symmetrical. organism: Human, ten healthy men tissue_or_cell_type: Serum carotenoid AUC over 24 hours experimental_model: Randomized-order double-blind crossover dosing experiment limitations: Acute high-dose study; does not justify routine co-supplementation or establish universal competition rules. exposure: 60 mg beta-carotene, 60 mg lycopene, or 60 mg of each together evidence_span: {"source_cache": "artifacts/lycopene-research/9278568.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e318f6fef0bfed88403fa2adf46f9713ebddfe6ea586c29614e820442c57d056", "start_char": 0, "end_char": 1510, "text_sha256": "e318f6fef0bfed88403fa2adf46f9713ebddfe6ea586c29614e820442c57d056"} [lycopene-p9278568] Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. (1997). https://pubmed.ncbi.nlm.nih.gov/9278568/ DOI: 10.1093/jn/127.9.1833
    Complete structured claim and evidence

  2. SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet.

    Scavenger receptor class B type 1 / SCARB1 → Intestinal beta-carotene absorption source_derived_draftungraded
    Experimental context and source evidence
    evidence_location
    Abstract
    experimental_model
    Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells.
    exposure
    Wild-type versus Scarb1-knockout mice; high-fat feeding.
    limitations
    Dependence was diet/model specific; this does not establish exclusive human transport.
    nutrient_topic
    Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
    organism
    Mus musculus
    outcome
    SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet.
    plain_language
    The intestinal receptor helps beta-carotene enter the body.
    primary_references
    [va-vanbennekum-2005] Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol (2005). https://pubmed.ncbi.nlm.nih.gov/15766282/ DOI: 10.1021/bi0484320
    tissue_or_cell_type
    Small-intestinal brush border
    transport_direction
    intestinal lumen to enterocyte

    Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 116–129

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells. · source_derived_draft · unverified_draft

    ### va-scarb1-beta-carotene-uptake SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: The intestinal receptor helps beta-carotene enter the body. organism: Mus musculus tissue_or_cell_type: Small-intestinal brush border experimental_model: Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells. limitations: Dependence was diet/model specific; this does not establish exclusive human transport. exposure: Wild-type versus Scarb1-knockout mice; high-fat feeding. outcome: SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet. evidence_location: Abstract transport_direction: intestinal lumen to enterocyte [va-vanbennekum-2005] Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol (2005). https://pubmed.ncbi.nlm.nih.gov/15766282/ DOI: 10.1021/bi0484320
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards