{"id":"47579e9d-4900-5a19-ba26-122d9ff04d12","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-scarb1-beta-carotene-uptake","predicate":"facilitates","statement":"SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7d9df27a-5213-5227-b6f7-9809f4ef62e1","mechanism_event_label":"The intestinal receptor helps beta-carotene enter the body.","subject":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"object":{"id":"4e488f1a-a028-542b-b550-4049cac7224e","slug":"intestinal-beta-carotene-absorption","display_name":"Intestinal beta-carotene absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7d9df27a-5213-5227-b6f7-9809f4ef62e1","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-scarb1-beta-carotene-uptake-event","event_type":"biochemical_relationship","label":"The intestinal receptor helps beta-carotene enter the body.","description":"SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"transported-substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4e488f1a-a028-542b-b550-4049cac7224e","slug":"intestinal-beta-carotene-absorption","display_name":"Intestinal beta-carotene absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Wild-type versus Scarb1-knockout mice; 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topical membership is not evidence of a direct dietary effect.\nplain_language: The intestinal receptor helps beta-carotene enter the body.\norganism: Mus musculus\ntissue_or_cell_type: Small-intestinal brush border\nexperimental_model: Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells.\nlimitations: Dependence was diet/model specific; this does not establish exclusive human transport.\nexposure: Wild-type versus Scarb1-knockout mice; high-fat feeding.\noutcome: SCARB1 supported intestinal beta-carotene absorption in mice on a high-fat diet.\nevidence_location: Abstract\ntransport_direction: intestinal lumen to enterocyte\n[va-vanbennekum-2005] Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol (2005). https://pubmed.ncbi.nlm.nih.gov/15766282/ DOI: 10.1021/bi0484320","model_system":"Scarb1-knockout mice, intestinal brush-border vesicles and transfected COS-7 cells.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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