Component

Intestinal alpha-tocopherol uptake

Uptake into intestinal epithelial cell models; distinct from whole-body bioavailability.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Co-incubated lutein reduced alpha-tocopherol uptake in Caco-2 TC-7 cells.

    Lutein → Intestinal alpha-tocopherol uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/16380385.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "410a6cc6c3325e6d2f459b06ddaf9c7b7806f9b82a918f1df02b1626f5f84074", "start_char": 0, "end_char": 1960, "text_sha256": "410a6cc6c3325e6d2f459b06ddaf9c7b7806f9b82a918f1df02b1626f5f84074"}
    experimental_model
    Mixed-micelle uptake in Caco-2 TC-7 cells
    exposure
    Alpha-tocopherol with co-incubated lutein
    limitations
    In vitro competition is not demonstrated vitamin E deficiency or a clinical dose-spacing rule.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human cell model
    plain_language
    Lutein and vitamin E can interact during intestinal uptake.
    primary_references
    [lutein-p16380385] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
    tissue_or_cell_type
    Intestinal epithelium

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 541–552

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mixed-micelle uptake in Caco-2 TC-7 cells · source_derived_draft · unverified_draft

    ### lutein-vitamin-e-competition Co-incubated lutein reduced alpha-tocopherol uptake in Caco-2 TC-7 cells. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lutein and vitamin E can interact during intestinal uptake. organism: Human cell model tissue_or_cell_type: Intestinal epithelium experimental_model: Mixed-micelle uptake in Caco-2 TC-7 cells limitations: In vitro competition is not demonstrated vitamin E deficiency or a clinical dose-spacing rule. exposure: Alpha-tocopherol with co-incubated lutein evidence_span: {"source_cache": "artifacts/lutein-research/16380385.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "410a6cc6c3325e6d2f459b06ddaf9c7b7806f9b82a918f1df02b1626f5f84074", "start_char": 0, "end_char": 1960, "text_sha256": "410a6cc6c3325e6d2f459b06ddaf9c7b7806f9b82a918f1df02b1626f5f84074"} [lutein-p16380385] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
    Complete structured claim and evidence

  2. Cholesterol inhibited human NPC1L1-mediated alpha-tocopherol uptake in mutual substrate-interaction experiments.

    Cholesterol → Intestinal alpha-tocopherol uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    true
    experimental_model
    Human NPC1L1 overexpression co-substrate assay
    exposure
    Cholesterol and alpha-tocopherol co-incubation; concentrations unavailable in abstract.
    limitations
    No dietary cholesterol threshold or universal supplement-spacing rule follows.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Human protein in cultured cells
    plain_language
    Cholesterol changed vitamin E uptake through their shared transporter.
    primary_references
    [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
    tissue_or_cell_type
    Cellular uptake model

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 220–231

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human NPC1L1 overexpression co-substrate assay · source_derived_draft · unverified_draft

    ### ve-transport-npc1l1-cholesterol-competition Cholesterol inhibited human NPC1L1-mediated alpha-tocopherol uptake in mutual substrate-interaction experiments. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Cholesterol changed vitamin E uptake through their shared transporter. organism: Human protein in cultured cells tissue_or_cell_type: Cellular uptake model experimental_model: Human NPC1L1 overexpression co-substrate assay limitations: No dietary cholesterol threshold or universal supplement-spacing rule follows. exposure: Cholesterol and alpha-tocopherol co-incubation; concentrations unavailable in abstract. cross_nutrient: true [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
    Complete structured claim and evidence

  3. Human NPC1L1 overexpression increased alpha-tocopherol uptake, which was inhibited by ezetimibe.

    Human Niemann-Pick C1-like protein 1 / NPC1L1 → Intestinal alpha-tocopherol uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Human NPC1L1 overexpression uptake assay
    exposure
    NPC1L1 expression with alpha-tocopherol and ezetimibe; dose/time not reported in abstract.
    limitations
    Cell experiment does not establish a clinical vitamin E deficiency from ezetimibe.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Human protein in cultured cells
    plain_language
    The cholesterol transporter NPC1L1 can also take up vitamin E.
    primary_references
    [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
    tissue_or_cell_type
    Cellular uptake model

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 207–218

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human NPC1L1 overexpression uptake assay · source_derived_draft · unverified_draft

    ### ve-transport-npc1l1-uptake Human NPC1L1 overexpression increased alpha-tocopherol uptake, which was inhibited by ezetimibe. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cholesterol transporter NPC1L1 can also take up vitamin E. organism: Human protein in cultured cells tissue_or_cell_type: Cellular uptake model experimental_model: Human NPC1L1 overexpression uptake assay limitations: Cell experiment does not establish a clinical vitamin E deficiency from ezetimibe. exposure: NPC1L1 expression with alpha-tocopherol and ezetimibe; dose/time not reported in abstract. cross_nutrient: false [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034
    Complete structured claim and evidence

  4. Blocking SR-BI with an extracellular antibody or BLT1 reduced RRR-alpha-tocopherol uptake by human Caco-2 TC7 cells.

    Scavenger receptor class B type 1 / SCARB1 → Intestinal alpha-tocopherol uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Differentiated Caco-2 TC7 monolayers
    exposure
    60-min pretreatment: antibody 3.75 µg/mL or BLT1 10 µM; 40 µM micellar RRR-alpha-tocopherol for 60 min.
    limitations
    Inhibitor/antibody evidence; contribution under these conditions is not the sole absorption route.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Homo sapiens
    plain_language
    SR-BI helped these intestinal cells take up vitamin E.
    primary_references
    [reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
    tissue_or_cell_type
    Intestinal epithelial cell model

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 181–192

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Differentiated Caco-2 TC7 monolayers · source_derived_draft · unverified_draft

    ### ve-transport-scarb1-uptake Blocking SR-BI with an extracellular antibody or BLT1 reduced RRR-alpha-tocopherol uptake by human Caco-2 TC7 cells. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: SR-BI helped these intestinal cells take up vitamin E. organism: Homo sapiens tissue_or_cell_type: Intestinal epithelial cell model experimental_model: Differentiated Caco-2 TC7 monolayers limitations: Inhibitor/antibody evidence; contribution under these conditions is not the sole absorption route. exposure: 60-min pretreatment: antibody 3.75 µg/mL or BLT1 10 µM; 40 µM micellar RRR-alpha-tocopherol for 60 min. cross_nutrient: false [reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards